Browsing Faculty of Health Sciences by Author "Hamman, Josias Hendrik"
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Efflux as a mechanism of antimicrobial drug resistance in clinical relevant microorganisms: the role of efflux inhibitors
Willers, Clarissa; Wentzel, Johannes Frederik; Du Plessis, Lissinda Hester; Gouws, Chrisna; Hamman, Josias Hendrik (Taylor & Francis, 2017)Introduction: Microbial resistance against antibiotics is a serious threat to the effective treatment of infectious diseases. Several mechanisms exist through which microorganisms can develop resistance against antimicrobial ... -
In vitro oral drug permeation models: the importance of taking physiological and physico-chemical factors into consideration
Joubert, Ruan; Steyn, Johan Dewald; Steenekamp, Jan Harm; Du Preez, Jan Lourens; Hamman, Josias Hendrik; Heystek, Hendrik Jacobus (Taylor & Francis, 2016)Introduction: The assessment of intestinal membrane permeability properties of new chemical entities is a crucial step in the drug discovery and development process and a variety of in vitro models, methods and techniques ...