Browsing Faculty of Health Sciences by Author "Zeevaart, Jan Rijn"
Now showing items 1-19 of 19
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99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles
Mandiwana, Vusani; Grobler, Anne; Zeevaart, Jan Rijn; Kalombo, Lonji (Elsevier, 2018)The aim of this study was to establish the in vivo uptake and tissue distribution of 99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive 99mTc-MDP encapsulated into SLNs was administered ... -
Bioaccumulation and subchronic toxicity of 14 nm gold nanoparticles in rats
Rambanapasi, Clinton; Zeevaart, Jan Rijn; Buntting, Hylton; Bester, Cornelius; Hayeshi, Rose; Grobler, Anne (MDPI, 2016)Colloidal suspensions of 14 nm gold nanoparticles (AuNPs) were repeatedly administered intravenously at three dose levels (0.9, 9 and 90 µg) to male Sprague Dawley rats weekly for 7 weeks, followed by a 14-day washout ... -
Biodistribution (as determined by the radiolabelled equivalent) of a gold(III) bis(pyrrolide-imine) Schiff base complex: a potential chemotherapeutic
Akerman, Matthew P.; Bester, Cornelius J.; Zeevaart, Jan Rijn; Munro, Orde Q.; Mongane, Modisenyane (Wiley, 2013)The biodistribution of an N2N2 0 tetradentate gold(III) chelate, which is known to be cytotoxic towards a range of human cancer cell lines, was determined by a radiolabelled equivalent of the compound. The 198Au-labelled ... -
Biodistribution and pharmacokinetics of I-131 labelled 4- Iodophenylacetic acid
Zeevaart, Jan Rijn; Szucs, Zoltan; Pulker, Tamsyn; Sello, Thato; Bracher, Jacqueline (Bentham Science, 2012)Abstract: Phenylacetate has been reported to have a potent anti-proliferative and anti-differentiating effect in haematological malignancies and in solid tumours at non-toxic concentrations. This study is a preliminary ... -
Biodistribution of a potential chemotherapeutic, dinuclearbisphosphinogold(I) dithiocarbamate, as determined by its 198Au radiolabelled analogue
Kriel, Frederik H.; Bester, Cornelius J.; Zeevaart, Jan Rijn; Szucs, Zoltan; Van Staden, Johan A. (Springer, 2015)Dinuclearbisphosphinogold(I) dithiocarbamato, BPDTC, was previously found to have antitumour activity in vitro. 198Au radiolabelled BPDTC (radiochemical yield of 70 ± 6 % and radiochemical purity of[95 %) was used to ... -
Complexation studies of 177Lu with ethylenediaminetetramethylene phosphonic acid (EDTMP) as a bone pain palliative therapeutic radiopharmaceutical
Sepini, Lebogang; Zeevaart, Jan Rijn; Jansen, David; Jarvis, Neil (Elsevier, 2016)Therapeutic radiopharmaceuticals for bone pain palliation play an important role in providing quality of life for cancer patients with metastatic bone cancer. There is currently interest in using 177Lu in many radiopharm ... -
Development of a single vial kit solution for radiolabeling of 68Ga-DKFZ-PSMA-11 and its performance in prostate cancer patients
Ebenhan, Thomas; Zeevaart, Jan Rijn; Vorster, Mariza; Marjanovic-Painter, Biljana; Wagener, Judith (MDPI, 2015)Prostate-specific membrane antigen (PSMA), a type II glycoprotein, is highly expressed in almost all prostate cancers. By playing such a universal role in the disease, PSMA provides a target for diagnostic imaging of ... -
Dual radiolabeling as a technique to track nanocarriers: the case of gold nanoparticles
Rambanapasi, Clinton; Barnard, Nicola; Grobler, Anne; Buntting, Hilton; Jordaan, Anine; Steyn, Hendrik; Zeevaart, Jan Rijn (MDPI, 2015)Gold nanoparticles (AuNPs) have shown great potential for use in nanomedicine and nanotechnologies due to their ease of synthesis and functionalization. However, their apparent biocompatibility and biodistribution is still ... -
Evaluation of a flexible NOTA-RGD kit solution using Gallium-68 from different 68Ge/ 68Ga-generators: pharmacokinetics and biodistribution in nonhuman primates and demonstration of solitary pulmonary nodule imaging in humans
Ebenhan, Thomas; Schoeman, Isabel; Grobler, Anne; Zeevaart, Jan Rijn; Rossouw, Daniel D. (Springer, 2016)Purpose: Radiopharmaceuticals containing the motive tripeptide arginyl-glycyl-asparatic acid (RGD) are known to target ανβ3 integrins during tumor angiogenesis. A more generic kit radiolabeling procedure accommodating ... -
In silico modelling in the development of novel radiolabelled peptide probes
Kleynhans, Janke; Cloete, Theunis; Zeevaart, Jan Rijn; Kruger, Hendrik Gerhardus; Ebenhan, Thomas (Bentham Science, 2020)This review describes the usefulness of in silico design approaches in the design of new radiopharmaceuticals, especially peptide-based radiotracers (including peptidomimetics). Although not part of the standard arsenal ... -
In vivo evaluation of acute intravenous toxicity of a [Ga-68]Ga-PSMA-11-microemulsion
Mandiwana, Vusani; Hayeshi, Rose; Zeevaart, Jan Rijn; Kalombo, Lonji M.; Labuschagne, Philip (Elsevier, 2020)Microemulsions (MEs) are reported to improve the efficacy of a drug, minimise side effects and toxicity of the encapsulated compound. MEs are hypothesized to aid in making the encapsulated compound, which has been incorporated ... -
Molecular imaging of a zirconium-89 labeled antibody targeting Plasmodium falciparum–infected human erythrocytes
Duvenhage, Janie; Zeevaart, Jan Rijn; Ebenhan, Thomas; Garny, Seike; Hernández González, Ignacio (Springer, 2020)Purpose Nuclear imaging is an important preclinical research tool to study infectious diseases in vivo and could be extended to investigate complex aspects of malaria infections. As such, we report for the first time ... -
Non-oncological applications of RGD-based single-photon emission tomography and positron emission tomography agents
Ebenhan, Thomas; Zeevaart, Jan Rijn; Kleynhans, Janke; Jeong, Jae Min; Sathekge, Mike (Springer, 2020)Introduction Non-invasive imaging techniques (especially single-photon emission tomography and positron emission tomography) apply several RGD-based imaging ligands developed during a vast number of preclinical and clinical ... -
Preclinical assessment of a 68Ga-DOTA-functionalized depsipeptide as a radiodiagnostic infection imaging agent
Ebenhan, Thomas; Zeevaart, Jan Rijn; Mokaleng, Botshelo Brenda; Venter, Jacobus Daniel; Kruger, Hendrik Gert (MDPI, 2017)The study assessed a radiolabeled depsipeptide conjugate (68Ga-DOTA-TBIA101) for its potential as an imaging agent targeting infection or infection-associated inflammation. 68Ga-labeled DOTA-TBIA101 imaging was performed ... -
Production of high specific activity 195mPt‐cisplatinum at South African Nuclear Energy Corporation for Phase 0 clinical trials in healthy individual subjects
Zeevaart, Jan Rijn; Wagener, Judith; Marjanovic-Painter, Biljana; Sathekge, Mike; Soni, Nischal (Wiley, 2013)Platinum agents continue to be the main chemotherapeutic agents used in the first-line and second-line treatments of cancer patients. It is important to fully understand the biological profile of these compounds in order ... -
Radiopharmaceutical enhancement by drug delivery systems: a review
Kleynhans, Janke; Grobler, Anne Frederica; Zeevaart, Jan Rijn; Ebenhan, Thomas; Sathekge, Mike Machaba (Elsevier, 2018)Introduction Drug delivery systems are entities designed to alter the biological behaviour of the pharmaceutical active ingredients that they carry in order to afford more beneficial biodistribution and safety profiles. ... -
Samarium oxide as a radiotracer to evaluate the in vivo biodistribution of PLGA nanoparticles
Mandiwana, Vusani; Grobler, Anne; Zeevaart, Jan Rijn; Kalombo, Lonji; Venter, Kobus (Springer, 2015)Developing nanoparticulate delivery systems that will allow easy movement and localization of a drug to the target tissue and provide more controlled release of the drug in vivo is a challenge in nanomedicine. The aim of ... -
Synthesis, in vitro evaluation, and 68Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection
Dutta, Jyotibon; Marjanovic-Painter, Biljana; Zeevaart, Jan Rijn; Baijnath, Sooraj; Somboro, Anou M. (Wiley, 2017)Bacterial infections are a major concern in the human health sector due to poor diagnosis and development of multidrug-resistant strains. PET/CT provides a means for the non-invasive detection and localization of the ... -
The use of cytokines and oxidative stress markers as indicators for drug safety
Griessel, Helene; Pheiffer, Wihan; Jansen van Rensburg, Emile; Zeevaart, Jan Rijn; Grobler, Anne F. (Elsevier, 2020)Safety and efficacy are of concern in developing new compounds. There is a paucity on the changes made by new compounds on inflammatory cytokines in combination with oxidative stress markers. Cytokines are potential markers ...