Browsing Faculty of Health Sciences by Subject "Benzonitrile"

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    • Monoamine oxidase inhibition by C4-substituted phthalonitriles 

      Manley-King, Clarina I.; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2012)
      It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms ...

    • Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B 

      Van der Walt, Mietha M.; Terre'Blanche, Gisella; Lourens, Anna C.U.; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2012)
      It has recently been reported that nitrile containing compounds frequently act as potent monoamine oxidase B (MAO-B) inhibitors. Modelling studies suggest that this high potency inhibition may rely, at least in part, on ...