Browsing Faculty of Health Sciences by Subject "P-glycoprotein"
Now showing items 1-5 of 5
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Absorptive and secretory transport of selected artemisinin derivatives across Caco-2 cell monolayers
(Bentham Science, 2018)Background: Malaria continues to be a major health concern and affects more than 200 million people a year. Drugs currently used for treatment of malaria are increasingly rendered ineffectual by the ongoing emergence of ... -
Combination therapy of western drugs and herbal medicines: recent advances in understanding interactions involving metabolism and efflux
(Taylor & Francis, 2012)Introduction: While complementary and alternative medicine markets prosper with an increasing number of consumers of herbal medicines, there is an associated likelihood for herb–drug interactions to occur. Modulation of ... -
Drug bioavailability enhancing agents of natural origin (bioenhancers) that modulate drug membrane permeation and pre-systemic metabolism
(MDPI, 2019)Many new chemical entities are discovered with high therapeutic potential, however, many of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility and/or poor membrane permeation characteristics. ... -
Excipient-drug pharmacokinetic interactions: effect of disintegrants on efflux across excised pig intestinal tissues
(Elsevier, 2018)Pharmaceutical excipients were designed originally to be pharmacologically inert. However, certain excipients were found to have altering effects on drug pharmacodynamics and/or pharmacokinetics. Pharmacokinetic interactions ... -
Herb-drug pharmacokinetic interactions: transport and metabolism of indinavir in the presence of selected herbal products
(MDPI, 2015)Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions ...