Now showing items 1-20 of 1448

    • 1,3,7-Triethyl-substituted xanthines-possess nanomolar affinity for the adenosine A1 receptor 

      Van der Walt, Mietha M.; Terre'Blanche, Gisella (Elsevier, 2015)
      Adenosine A1 receptors are attracting great interest as drug targets for their role in cognitive deficits. Antagonism of the adenosine A1 receptor may offer therapeutic benefits in complex neurological diseases, such as ...
    • 1-Bromo-2-(10 β-dihydroartemisinoxy)ethane 

      Lombard, Marli C.; Fernandes, Manuel A.; Breytenbach, Jaco C.; N'Da, David D. (International Union of Crystallography (IUCr), 2010)
      The title compound, C17H27BrO5, DEB, is a derivative of artemisinin which is used in malaria therapy. The OR-group at C12 is cis to the CH3-group at C11 and axially oriented on ring D which has a chair conformation. The ...
    • 2-Acetylphenol analogs as potent reversible monoamine oxidase inhibitors 

      Legoabe, Lesetja J.; Petzer, Anél; Petzer, Jacobus P. (Dove Press, 2015)
      Based on a previous report that substituted 2-acetylphenols may be promising leads for the design of novel monoamine oxidase (MAO) inhibitors, a series of C5-substituted 2-acetylphenol analogs (15) and related compounds ...
    • 2-Aminopyrimidines as dual adenosine A1/A2A antagonists 

      Robinson, Sarel J.; Petzer, Jacobus P.; Terre'Blanche, Gisella; Petzer, Anél; Van der Walt, Mietha M.; Bergh, Jacobus J.; Lourens, Anna C.U. (Elsevier, 2015)
      In this study thirteen 2-aminopyrimidine derivatives were synthesised and screened as potential antagonists of adenosine A1 and A2A receptors in order to further investigate the structure activity relationships of this ...
    • 2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase 

      Nel, Magdalena S.; Petzer, Anél; Petzer, Jacobus P.; Legoabe, Lesetja J. (Elsevier, 2016)
      In the present study, a series of twenty-two 2-benzylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 2-benzylidene-1-indanone derivatives ...
    • A 2-Decade Appraisal of African Nursing Scholarship: 1986-2006 

      Lekalakala-mokgele, Eucebious; Oluyinka, Adejumo (Wiley-Blackwell, 2009)
      This paper is a description of a study about articles published about nursing in Africa from 1986 to 2006. METHODS: An exhaustive database search of articles written by nurses or articles related to nursing in Africa was ...
    • 2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase 

      Nel, Magdalena S.; Petzer, Anél; Petzer, Jacobus P.; Legoabe, Lesetja J. (Elsevier, 2016)
      In the present study a series of fifteen 2-heteroarylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. These compounds are structurally related ...
    • 25 Years of research on global asphyxia in the immature rat brain 

      Barkhuizen, M.; Van den Hove, D.L.A.; Vles, J.S.H.; Steinbusch, H.W.M.; Kramer, B.W. (Elsevier, 2017)
      Hypoxic-ischemic encephalopathy remains a common cause of brain damage in neonates. Preterm infants have additional complications, as prematurity by itself increases the risk of encephalopathy. Currently, therapy for this ...
    • 3-Coumaranone derivatives as inhibitors of monoamine oxidase 

      Van Dyk, Adriaan S.; Petzer, Jacobus P.; Petzer, Anél; Legoabe, Lesetja J. (Dove Press, 2015)
      The present study examines the monoamine oxidase (MAO) inhibitory properties of a series of 20 3-coumaranone [benzofuran-3(2H)-one] derivatives. The 3-coumaranone derivatives are structurally related to series of α-tetralone ...
    • 8-Aryl- and alkyloxycaffeine analogues as inhibitors of monoamine oxidase 

      Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Strydom, Belinda (Elsevier, 2011)
      Recently it was reported that a series of 8-benzyloxycaffeine analogues are potent reversible inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to discover additional C8 oxy substituents of caffeine that ...
    • 8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: The SABPA study 

      Mels, C.M.C.; Schutte, A.E.; Schutte, R.; Smith, W.; Huisman, H.W.; Fourie, C.M.T.; Van Rooyen, J.M.; Kruger, R.; Malan, N.T.; Malan, L. (Taylor & Francis, 2014)
      Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study ...
    • A biomarker of tissue damage, lactate dehydrogenase, is associated with fibulin-1 and oxidative stress in blacks: the SAfrEIC study 

      Mokwatsi, Gontse G.; Schutte, Aletta E.; Kruger, Ruan (Taylor & Francis Ltd, 2016)
      Context: Extracellular matrix (ECM) remodeling and oxidative stress is present in hypertension and associated arterial stiffness, but little is known on the physiological link among lactate dehydrogenase (LDH), fibulin-1, ...
    • A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension 

      Olsen, Michael H.; Schutte, Aletta E.; Angell, Sonia Y.; Asma, Samira; Boutouyrie, Pierre (Elsevier Science Inc, 2016)
      Elevated blood pressure is the strongest modifiable risk factor for cardiovascular disease worldwide. Despite extensive knowledge about ways to prevent as well as to treat hypertension, the global incidence and prevalence ...
    • A century of trends in adult human height 

      Bentham, James; Kruger, Herculina S.; Schutte, Aletta E.; Di Sesare, Maria; Stevens, Gretchen A. (eLife Sciences Publications Ltd, 2016)
      Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height ...
    • A community ''Hub'' network intervention for HIV stigma reduction: a case study 

      Prinsloo, Catharina D.; Greeff, Minrie (Elsevier, 2016)
      We describe the implementation of a community “hub” network intervention to reduce HIV stigma in the Tlokwe Municipality, North West Province, South Africa. A holistic case study design was used, focusing on community ...
    • A community-based HIV stigma reduction intervention for people living with HIV and their partners 

      Louwrens, M.H.; Greeff, Minrie; Manyedi, M. Eva (UP, 2016)
      The diagnosis of HIV impacts the lives and the relationships of both people living with HIV (PLWH) and their partners. The researchers aimed to describe the influence of a community-based HIV stigma reduction intervention ...
    • A dose-response crossover iodine balance study to determine iodine requirements in early infancy 

      Dold, Susanne; Baumgartner, Jeannine; Zimmermann, Michael B.; Davaz, Tabea; Galetti, Valeria (American Society for Nutrition, 2016)
      Background: Optimal iodine intake during infancy is critical for brain development, but no estimated average requirement (EAR) is available for this age group. Objective: We measured daily iodine intake, excretion, and ...
    • A HIV stigma reduction intervention for people living with HIV and their families 

      Pretorius, Johanna Beatrix; Greeff, Minrie; Freeks, Fazel Ebrihiam; Kruger, Annamarie (Elsevier, 2016)
      Background The diagnosis of HIV is life-changing that requires people not only to deal with the disease but also to cope with the stigma attached to HIV. People living with HIV (PLWH) as well as their close family members ...
    • A supervision tool to guide postgraduate students during research supervision 

      Grobler, Hermanus Bosman (Unisa Press Host: Dept Social Work, UJ, 2015)
      It is not uncommon for postgraduate students to postpone or terminate their studies due to emotional and/or academic reasons. The purpose of this research–based article is to propose a specific supervision tool ...
    • A synthesis of homelessness in South Africa: a rapid critical appraisal 

      Roets, Leon; Greeff, Minrie; Strydom, Herman; Watson, Martha J.; Chigeza, Shingairai (Taylor & Francis, 2016)
      Homelessness in South Africa requires collaborative research. Social, political, cultural and economic factors that cause homelessness must be considered to develop a common definition and understanding of homelessness. ...