Browsing Faculty of Health Sciences by Author "10060871 - Malan, Leoné"
Now showing items 1-20 of 125
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8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA study
Mels, C.M.C.; Schutte, A.E.; Schutte, R.; Pretorius, P.J.; Smith, W.; Huisman, H.W.; Van der Westhuizen, F.H.; Fourie, C.M.T.; Van Rooyen, J.M.; Kruger, R.; Louw, R.; Malan, N.T.; Malan, L. (Taylor & Francis, 2014)Various studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study ... -
Adipokines and cardiometabolic function: how are they interlinked?
Schutte, Aletta Elisabeth; Huisman, Hugo Willem; Schutte, Rudolph; Van Rooyen, Johannes Marthinus; Malan, Leoné; Fourie, Catharina Maria Theresia; Malan, Nicolaas Theodor (Elsevier, 2010)Objective Adipokines contribute directly to the coexistence of insulin resistance and endothelial dysfunction. Most studies focus on a single adipokine. We therefore investigated the independent relationships of leptin, ... -
Alkaline phosphatase and arterial structure and function in hypertensive African men: the SABPA study
Schutte, R.; Huisman, H.W,; Malan, L.; Van Rooyen, J.M.; Smith, W. (Elsevier, 2013)Background: Vascular calcification is believed to be due to the conversion of vascular smooth muscle cells into osteoblast-like cells and is associated with mortality. Since hypertension and related mortality in Africans ... -
Ambulatory blood pressure monitoring and morning surge in blood pressure in adult black and white South Africans
Lambert, Gavin W.; Malan, Nicolaas T.; Malan, Leoné; Head, Geoffrey A.; Chen, Won Sun (Wiley, 2020)We examined whether there were differences in the circadian variation in blood pressure and the morning surge in blood pressure between black and white Africans. Clinic and ambulatory blood pressure data obtained from the ... -
Arterial stiffness profiles: investigating various sections of the arterial tree of African and caucasian people
Huisman, Hugo Willem; Malan, Nicolaas Theodor; Schutte, Aletta Elisabeth; Schutte, Rudolph; Van Rooyen, Johannes Marthinus; Malan, Leoné; Reimann, Manja (Informa healthcare, 2011)In Africans, arterial stiffness progression seems more pronounced compared to Caucasians. We compared the arterial stiffness profiles of different age groups and focused on muscular arteries and two more central arterial ... -
Arterial stiffness, ambulatory blood pressure and low-grade albuminuria in non-diabetic African and caucasian men: the SABPA study
Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Glyn, Matthew C.P.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Fourie, Carla M.T.; Malan, Leoné (Nature Publishing Group, 2011)Recent evidence suggests that low-grade urinary albumin excretion is a marker of early general attenuation of vascular function, but studies are limited to Caucasian population groups. We compared low-grade urinary albumin ... -
The association between anthopometric parameters, the metabolic syndrome and microalbuminuria in black Africans: The SABPA study
Hoebel, S.; De Ridder, J.H.; Malan, L. (Clinics Cardive Publishing Ltd, 2010) -
Association between nutritional awareness and diet quality: evidence from the observation of cardiovascular risk factors in Luxembourg (ORISCAV–LUX) study
Alkerwi, Ala'a; Sauvageot, Nicolas; Malan, Leoné; Shivappa, Nitin; Hébert, James R. (Mdpi Ag, 2015)This study examined the association between nutritional awareness and diet quality, as indicated by energy density, dietary diversity and adequacy to achieve dietary recommendations, while considering the potentially ... -
Association between objectively measured physical activity, chronic stress and leukocyte telomere length
Von Känel, Roland; Bruwer, Erna J.; De Ridder, J. Hans; Malan, Leoné; Hamer, Mark (Edizioni Minerva Medica, 2017)BACKGROUND: Physical activity (PA ) attenuates chronic stress and age-related and cardiovascular disease risks, whereby potentially slowing telomere shortening. We aimed to study the association between seven-day objectively ... -
The association between seven-day objectively measured habitual physical activity and 24 h ambulatory blood pressure: the SABPA study
Hamer, M.; Bruwer, E.J.; De Ridder, J.H.; Swanepoel, M.; Cockeran, M.; Malan, L. (Springer Nature, 2017)Few studies have examined objective physical activity in relation to 24 h ambulatory blood pressure (BP). We aimed to assess the association of 7-day objectively measured habitual physical activity with ambulatory BP in a ... -
The association of 25(OH)D with blood pressure, pulse pressure and carotid–radial pulse wave velocity in African women
Kruger, Iolanthé M.; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Schutte, Rudolph; Malan, Leoné; Malan, Nicolaas T.; Fourie, Carla M.T.; Kruger, Annamarie (Public Library of Science, 2013)High susceptibility of the African population to develop cardiovascular disease obliges us to investigate possible contributing risk factors. Our aim was to determine whether low 25(OH)D status is associated with increased ... -
The Association of Red Blood Cell Counts with Endothelin-1 in African and Caucasian Women
Huisman, Hugo W.; Schutte, Aletta E.; Van Rooyen, Johannes M.; Schutte, Rudolph; Malan, Leoné; Fourie, Catharina M.T.; Malan, Nicolaas T. (Informa Healthcare, 2009)The literature shows an increase in endothelin-1 with increased levels of erythrocytes. There are also indications that inflammation and elevated endothelin-1 levels interact with erythropoiesis. In this study, the association ... -
Association of waist circumference with perception of own health in urban African males and females: the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study
Botha, J.; Malan, L.; Potgieter, J.C.; Steyn, H.S.; De Ridder, J.H. (Taylor & Francis, 2012)Background: Current waist circumference (WC) cut-points of the Joint Statement Consensus (JSC) (male ≥ 94 cm, female ≥ 80 cm) were compared with a recently proposed WC cut-point (RPWC) (male ≥ 90 cm, female ≥ 98 cm). In ... -
Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study
Kruger, R.; Schutte, R.; Huisman, H.W.; Van Rooyen, J.M.; Malan, N.T.; Fourie, C.M.T.; Louw, R.; Van der Westhuizen, F.H.; Van Deventer, C.A.; Malan, L.; Schutte, A.E. (Springer Nature, 2012)Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory ... -
Associations of cholesterol and glucose with cardiovascular dysfunction in black Africans: the SABPA study
Lammertyn, Leandi; Schutte, Rudolph; Schutte, Aletta E.; Huisman, Hugo W.; Van Rooyen, Johannes M.; Malan, Nicolaas T.; Fourie, Carla M.T.; Malan, Leoné (Informa healthcare, 2011)The aim was to determine whether blood glucose or cholesterol is the more prominent contributor to cardiovascular dysfunction in 101 African men and 99 African women. We measured ambulatory daytime blood pressure (BP), ... -
Asymmetric dimethylarginine and symmetric dimethylarginine prospectively relates to carotid wall thickening in black men: the SABPA study
Mels, Catharina M.C.; Schutte, A.E.; Huisman, H.W.; Smith, W.; Kruger, R.; Van Rooyen, J.M.; Malan, N.T.; Malan, L. (Springer, 2017)The relationship of both asymmetric (ADMA) and symmetric (SDMA) dimethylarginine with carotid wall thickness is inconclusive especially among black populations. We aimed to compare carotid intima media thickness (cIMT) and ... -
Attenuated brain-derived neurotrophic factor and hypertrophic remodelling: the SABPA study
Smith, A.J.; Malan, L.; Uys, A.S.; Malan, N.T.; Harvey, B.H. (Springer Nature, 2015)Brain-derived neurotrophic factor (BDNF) has been linked to neurological pathologies, but its role in cardiometabolic disturbances is limited. We aimed to assess the association between serum BDNF levels and structural ... -
Attenuated NOx responses and myocardial ischemia, a possible risk for structural vascular disease in African men: the SABPA study
Uys, A.S.; Malan, L.; Van Rooyen, J.M.; Steyn, H.S.; Reimann, M. (Nature Publishing Group, 2014)Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite ... -
Baroreceptor sensitivity, cardiovascular responses and ECG left ventricular hypertrophy in men: the SABPA study
Steyn, Hendrik Stefanus; Van Rooyen, Johannes Marthinus; Van Lill, Lisa; Malan, Leoné; Reimann, Manja; Ziemssen, Tjalf (Informa Health care, 2011)Aim. Research has shown a significant relationship between hypertension and attenuated baroreceptor sensitivity (BRS), which in turn reflects alterations of autonomic control of the cardiovascular system. The objective of ... -
BDNF increases associated with constant troponin T levels and may protect against poor cognitive interference control: the SABPA prospective study
Jansen van Vuren, Esmé; Malan, Leoné; Von Känel, Roland; Lammertyn, Leandi; Malan, Nicolaas T. (Wiley, 2019)Background: Brain‐derived neurotrophic factor (BDNF) modulates brain health and cognition, which can interfere with executive cognitive function. BDNF was impli-cated with microcirculatory ischaemia and may reflect ...