Browsing Faculty of Health Sciences by Author "11320036 - Viljoen, Johanna Magdalena"
Now showing items 1-15 of 15
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Anti-melanoma activities of artemisone and prenylated amino-artemisinins in combination with known anticancer drugs
Wong, Ho Ning; Lewies, Angélique; Haigh, Michaela; Viljoen, Joe M.; Wentzel, Johannes F.; Haynes, Richard K.; Du Plessis, Lissinda H. (Frontiers Media, 2020)The most frequently occurring cancers are those of the skin, with melanoma being the leading cause of death due to skin cancer. Breakthroughs in chemotherapy have been achieved in certain cases, though only marginal advances ... -
Characterization of solid lipid dispersions prepared by hot fusion containing a double-fixed dose combination of artemether and lumefantrine
Wilkins, Christi A.; Du Plessis, Lissinda H.; Viljoen, Joe M. (Taylor & Francis, 2020)bjective The World Health Organization has called for the development of novel drug delivery systems to combat malaria – the fourth most prevalent cause of death globally. The plausibility of utilizing hot fusion to prepare ... -
Cutaneous tuberculosis overview and current treatment regimens
Van Zyl, Lindi; Du Plessis, Jeanetta; Viljoen, Joe (Elsevier, 2015)Tuberculosis is one of the oldest diseases known to humankind and it is currently a worldwide threat with 8e9 million new active disease being reported every year. Among patients with co-infection of the human immunodeficiency ... -
Development and validation of the simultaneous determination of artemisone, clofazimine and decoquinate with HPLC
Du Preez, J.L.; Aucamp, M.E.; Burger, C.; Gerber, M.; Viljoen, J.M.; Van Zyl, L.; Du Plessis, J. (Avoxa, 2018)The aim of this study was to develop and validate a novel HPLC method for the simultaneous analysis of artemisone, clofazimine and decoquinate. Detection was obtained at two wavelengths; 284 nm (clofazimine) and 210 nm ... -
Development of a self-emulsifying drug delivery system for optimized topical delivery of clofazimine
Van Staden, Daniélle; Du Plessis, Jeanetta; Viljoen, Joe (MDPI, 2020)A quality-by-design and characterization approach was followed to ensure development of self-emulsifying drug delivery systems (SEDDSs) destined for topical delivery of the highly lipophilic clofazimine. Solubility and ... -
Development of topical/transdermal self-emulsifying drug delivery systems, not as simple as expected
Van Staden, Daniélle; Du Plessis, Jeanetta; Viljoen, Joe (MDPI, 2020)Self-emulsifying drug delivery systems (SEDDSs) originated as an oral lipid-based drug delivery system with the sole purpose of improving delivery of highly lipophilic drugs. However, the revolutionary drug delivery ... -
Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets
Viljoen, Joe M.; Steenekamp, Jan H.; Marais, Andries F.; Kotzé, Awie F. (Taylor & Francis, 2014)Context: Chitosan does not rank highly regarding its employment as tablet filler due to certain limitations. Undesirable properties that limit its utilization as excipient in solid dosage forms include its hydration ... -
Essential fatty acids as transdermal penetration enhancers
Van Zyl, Lindi; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta; Viljoen, Joe (Elsevier, 2016)The aim of this study was to investigate the effect of different penetration enhancers, containing essential fatty acids (EFAs), on the transdermal delivery of flurbiprofen. Evening primrose oil (EPO), vitamin F and Pheroid™ ... -
Formulation and evaluation of selected transmucosal dosage forms containing a double fixed-dose of acyclovir and ketoconazole
Viljoen, Joe M.; Botes, Danélia; Steenekamp, Jan H. (Elsevier, 2018)Viral and fungal dermatological manifestations are often the first and only sign of HIV/AIDS. They are cosmetically disfiguring and threaten the quality of life, but can be treated by acyclovir and ketoconazole, correspondingly. ... -
Herb-drug pharmacokinetic interactions: transport and metabolism of indinavir in the presence of selected herbal products
Calitz, Carlemi; Gouws, Chrisna; Viljoen, Joe; Steenekamp, Jan; Hamman, Josias (MDPI, 2015)Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions ... -
Impact of traditional African medicine on drug metabolism and transport
Calitz, Carlemi; Steenekamp, Jan H.; Steyn, Johan D.; Gouws, Chrisna; Viljoen, Joe M.; Hamman, Josias H. (Taylor & Francis, 2014)Introduction: Africa is a continent of rich plant biodiversity with many indigenous plants having a long history of being used for medicinal purposes. A considerable number of patients consult traditional healers in ... -
In-vitro cytotoxicity of various Siphonochilus aethiopicus (Schweinf.) B.L. Burtt extracts in combination with selected tableting excipients
Erasmus, Mandi; Du Plessis, Lissinda H.; Viljoen, Joe M. (Wiley, 2019)Objectives To investigate the cytotoxic potential of S. aethiopicus extracts in combination with chitosan and Pharmacel 101, on two cell lines. Methods Extracts were chemically characterised utilising UPLC-Q-TOF/MS, ... -
Novel non-invasive protein and peptide drug delivery approaches
Wallis, Lonette; Kleynhans, Elmarie; Du Toit, Trizel; Gouws, Chrisna; Steyn, Dewald; Steenekamp, Jan; Viljoen, Joe; Hamman, Josias (Bentham Science, 2014)Protein and peptide based therapeutics are typically administered by injection due to their poor uptake when administered via enteral routes of drug administration. Unfortunately, chronic administration of these drugs ... -
Penetration enhancing effects of selected natural oils utilized in topical dosage forms
Viljoen, Joe M.; Cowley, Amé; Du Preez, Jan; Gerber, Minja; Du Plessis, Jeanetta (Taylor & Francis, 2015)Context: Various natural products, including oils, have been utilized as penetration enhancers due to their “safety profiles”. These oils contain fatty acids promoting skin permeability through lipid fluidization within ... -
Topical delivery of artemisone, clofazimine and decoquinate encapsulated in vesicles and their in vitro efficacy against Mycobacterium tuberculosis
Van Zyl, Lindi; Viljoen, Joe M.; Haynes, Richard k.; Aucamp, Marique; Du Plessis, Jeanetta (Springer, 2019)Vesicles are widely investigated as carrier systems for active pharmaceutical ingredients (APIs). For topical delivery, they are especially effective since they create a “depot-effect” thereby concentrating the APIs in the ...