Browsing Faculty of Health Sciences by Author "12776998 - Franken, Anja"
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Assessment of dermal exposure and skin condition of workers exposed to nickel at a South African base metal refinery
Du Plessis, Johannes L.; Eloff, Frederik C.; Badenhorst, Casper J.; Olivier, Johretha; Laubscher, Petrus J.; Van Aarde, Michiel N.; Franken, Anja (Oxford Univ Press, 2010)Objectives: The objectives of this study were to assess dermal exposure of cell workers to nickel at a South African base metal refinery and to characterize their skin condition by measuring the skin hydration and trans ... -
Characterisation of and exposure of workers to tailings dust at South African platinum mines
Franken, Anja; Eloff, Frederik; Du Plessis, Johannes; Van Aarde, Michiel; Laubscher, Petrus (Mine Ventiliation Society of South Africa, 2009)The National Institute for Occupational Safety and Health (NIOSH) has conducted research to improve the ventilation of large-opening mines whose entries are at least 93m2 (1,000 ft2). The ventilation of large-opening mines ... -
Comparison of South African skin and sensitisation notations with those of other countries
Du Plessis, Johannes Lodewykus; Eloff, Frederik Christoffel; Franken, Anja; Laubscher, Petrus Johannes; Van Aarde, Michiel Nicolaas (Occupational Health Southern Africa, 2010)South African skin notations listed in the Regulations for Hazardous Chemical Substances (RHCS) and Mine Health and Safety Regulations (MHSR) were compared to those of selected other developed countries in order to ascertain ... -
Dermal exposure and changes in skin barrier function of base metal refinery workers co-exposed to cobalt and nickel
Du Plessis, J.L.; Eloff, F.C.; Engelbrecht, S.; Laubscher, P.J.; Van Aarde, M.N.; Franken, A. (The South African Society of Occupational Medicin, 2013)Refi nery workers are exposed to many metals, including cobalt and nickel, both of which are skin sensitisers, causing allergic contact dermatitis. Dermal exposure, and changes in skin barrier function [skin hydration, ... -
DNA damage and repair capacity in hairdressers exposed to chemical products: a pilot study
Eloff, F.C.; Preston, R.; Pretorius, P.J.; Du Plessis, J.L.; Laubscher, P.J.; Van Aarde, M.N.; Van der Westhuizen, F.H.; Franken, A. (SASOM, 2013)Hairdressers are exposed to numerous hazardous chemical substances, some of which are known or suspected allergens, carcinogens or organic solvents. The objectives of this study were to compare DNA damage and DNA repair ... -
The evaluation and quantification of respirable coal and silica dust concentrations: a task-based approach
Grové, T.; Franken, A.; Du Plessis, J.; Van Dyk, T. (Taylor & Francis, 2014)Silicosis and coal worker's pneumoconiosis are serious occupational respiratory diseases associated with the coal mining industry and the inhalation of respirable dusts containing crystalline silica. The purpose of this ... -
Flow cytometric analysis of the oxidative status in human peripheral blood mononuclear cells of workers exposed to welding fumes
Du Plessis, Lissinda; Laubscher, Petrus; Jooste, Jacques; Du Plessis, Johan; Franken, Anja; Van Aarde, Nico; Eloff, Fritz (Taylor & Francis, 2010)Flow cytometry is a simple analytical technique that identifies, counts, and characterizes cells. The oxidative status of cells is influenced by many exogenous sources, such as occupational exposure to welding fumes. This ... -
In vitro permeation of metals through human skin: a review and recommendations
Franken, Anja; Eloff, Frederik C.; Du Plessis, Jeanetta; Du Plessis, Johannes L. (American Chemical Society, 2015)During the last few decades, the interest in skin permeation of, specifically, metals has increased with the in vitro method utilizing diffusion cells as the prominent method of investigating permeability. This review ... -
In vitro permeation of platinum and rhodium through Caucasian skin
Franken, A.; Eloff, F.C.; Du Plessis, J.; Badenhorst, C.J.; Jordaan, A.; Du Plessis, J.L. (Elsevier, 2014)During platinum group metals (PGMs) refining the possibility exists for dermal exposure to PGM salts. The dermal route has been questioned as an alternative route of exposure that could contribute to employee sensitisation, ... -
In vitro permeation of platinum through African and Caucasian skin
Franken, A.; Eloff, F.C.; Du Plessis, J.; Badenhorst, C.J.; Du Plessis, J.L. (Elsevier, 2015)The majority of the South African workforce are Africans, therefore potential racial differences should be considered in risk and exposure assessments in the workplace. Literature suggests African skin to be a superior ... -
The influence of pH on the in vitro permeation of rhodium through human skin
Jansen van Rensburg, Sané; Franken, Anja; Du Plessis, Jeanetta; Du Plessis, Johannes Lodewykus (Sage, 2017)Workers in precious metals refineries are at risk of exposure to salt compounds of the platinum group metals through inhalation, as well as through the skin. Rhodium salt permeation through the skin has previously been ... -
The influence of vibration and noise from a handheld pneumatic (sculptors) chisel on the human cardiovascular system
Franken, Anja; Eloff, Frederik; Du Plessis, Johannes; Van Aarde, Michiel; Laubscher, Petrus (Mine Ventiliation Society of South Africa, 2009)Noise-induced hearing loss (NIHL) in the South African mining industry can be prevented, but only by incorporating more proactive and innovative measures into NIHL prevention programmes. At present, direct and indirect ... -
International guidelines for the in vivo assessment of skin properties in non–clinical settings. Part 2. Transepidermal water loss and skin hydration
Du Plessis, Johan; Eloff, Fritz; Franken, Anja; Stefaniak, Aleksandr; John, Swen (Wiley, 2013)Background: There is an emerging perspective that it is not sufficient to just assess skin exposure to physical and chemical stressors in workplaces, but that it is also important to assess the condition, i.e. skin ... -
Measurement of transepidermal water loss, stratum corneum hydration and skin surface pH in occupational settings: a review
Jansen van Rensburg, Sané; Franken, Anja; Du Plessis, Johannes Lodewykus (Wiley, 2019)Background: The skin provides a permeable barrier which may be impaired in oc‐ cupational settings. Transepidermal water loss (TEWL), stratum corneum hydration (SCH) and skin surface pH (SSpH) have been used in occupational ... -
Occupational respiratory exposure to platinum group metals: a review and recommendations
Linde, Stephanus J.L.; Franken, Anja; Du Plessis, Johannes L. (ACS, 2017)Platinum group metals (PGMs) is a group of metals that include platinum, palladium, rhodium, ruthenium, iridium, and osmium. Occupational respiratory exposure to platinum has been reported since 1945, but studies investigating ... -
Particle size and metal composition of gouging and lancing fumes
Keyter, Marelé; Van der Merwe, Alicia; Franken, Anja (Taylor & Francis, 2019)Metal gouging and lancing liberate particles of an unknown size and composition. Fumes are formed when vaporized materials condense in air, creating fine and ultrafine particles which can agglomerate. Particle sizes may ... -
Reflections on the OECD guidelines for in vitro skin absorption studies
Hopf, N.B.; Du Plessis, J.L.; Franken, A.; Frasch, F.; Champmartin, C.; Schenk, L.; Berthet, A.; Chedik, L.; Gaskin, S. (Elsevier, 2020)At the 8th conference of Occupational and Environmental Exposure of the Skin to Chemicals (OEESC) (16–18 September 2019) in Dublin, Ireland, several researchers performing skin permeation assays convened to discuss in vitro ... -
Transepidermal water loss, stratum corneum hydration, and skin surface pH of female African and Caucasian nursing students
Young, Monica M.; Franken, Anja; Du Plessis, Johan L. (Wiley, 2018)Background Conflicting evidence exists on how skin barrier function compares between Africans and Caucasians. This study measured skin barrier function of South African first year nursing students before their practical ... -
Urinary excretion of platinum (Pt) following skin and respiratory exposure to soluble Pt at South African precious metals refineries
Linde, Stephanus J.L.; Franken, Anja; Du Plessis, Johannes L. (Elsevier, 2018)Adverse respiratory and skin health effects have been associated with occupational exposure to soluble platinum (Pt). However, the relationship between skin exposure and urinary Pt excretion has not yet been investigated. ... -
Urinary excretion of platinum from South African precious metals refinery workers
Linde, Stephanus J.L.; Franken, Anja; Du Plessis, Johannes L. (BMJ Publishing Group, 2018)Background Urinary platinum (Pt) excretion is a reliable biomarker for occupational Pt exposure and has been previously reported for precious metals refinery workers in Europe but not for South Africa, the world’s largest ...