Browsing Faculty of Health Sciences by Author "22353003 - Wegener, Gregers"
Now showing items 1-20 of 57
-
3D analysis of synaptic vesicle density and distribution after acute foot‐shock stress by using serial section transmission electron microscopy
Khanmohammadi, M.; Wegener, G.; Darkner, S.; Nava, N.; Nyengaard, J.R. (Wiley, 2017)Behavioural stress has shown to strongly affect neurotransmission within the neocortex. In this study, we analysed the effect of an acute stress model on density and distribution of neurotransmitter‐containing vesicles ... -
Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression
Melas, P.A.; Wegener, G.; Lennartsson, A.; Vakifahmetoglu-Norberg, H.; Wei, Y. (Springer Nature, 2013)Neuropeptide Y (NPY) has been implicated in depression, emotional processing and stress response. Part of this evidence originates from human single-nucleotide polymorphism (SNP) studies. In the present study, we report ... -
Antidepressant efficacy of high and low frequency transcranial magnetic stimulation in the FSL/FRL genetic rat model of depression
Hesselberg, Marie Louise; Wegener, Gregers; Buchholtz, Poul Erik (Elsevier, 2016)Repetitive Magnetic Stimulation (rTMS) has appeared to be a potential non-invasive antidepressant method, which implies non-convulsive focal stimulation of the brain through a time varying magnetic field. The antidepressant ... -
Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene
Wei, Ya Bin; Wegener, Gregers; Melas, Philippe A.; Mathé, Aleksander A.; Lavebratt, Catharina (Oxford Univ Press, 2015)Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has ... -
Autistic-like behaviours and associated brain structural plasticity are modulated by oxytocin in maternally separated rats
Mansouri, Monireh; Wegener, Gregers; Pouretemad, Hamidreza; Roghani, Mehrdad; Ardalan, Maryam (Elsevier, 2020)Background Early psycho-social experiences influence the developing brain and possible onset of various neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD). ASD is characterized by a variety of brain ... -
Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine
Tornese, Paolo; Wegener, Gregers; Sala, Nathalie; Bonini, Daniela; Bonifacino, Tiziana (Elsevier, 2019)Depression is a debilitating mental disease, characterized by persistent low mood and anhedonia. Stress represents a major environmental risk factor for depression; the complex interaction of stress with genetic factors ... -
Chronic restraint stress increases the protein expression of VEGF and its receptor VEGFR-2 in the prefrontal cortex
Elfving, Betina; Wegener, Gregers; Jakobsen, Jakob Lerche; Madsen, Jens Christian Bredahl; Müller, Heidi Kaastrup (Wiley, 2015)In the present study the central and peripheral regulation of VEGF, its cognate receptors, and regulators were examined after acute and chronic restraint stress in rats. After chronic restraint stress (6 h per day for 21 ... -
Cortical and striatal serotonin transporter binding in a genetic rat model of depression and in response to electroconvulsive stimuli
Hvilsom, Anna Sophie Thue; Wegener, Gregers; Lillethorup, Thea P.; Iversen, Peter; Doudet, Doris J. (Elsevier, 2019)Depression is a debilitating mental illness and two thirds of patients respond insufficiently to conventional antidepressants. Electroconvulsive therapy (ECT) remains the most effective treatment to alleviate drug-refractory ... -
A critical role of mitochondria in BDNF-associated synaptic plasticity after one-week vortioxetine treatment
Chen, Fenghua; Wegener, Gregers; Danladi, Jibrin; Ardalan, Maryam; Elfving, Betina (Oxford Univ Press, 2018)Background Preclinical studies have indicated that antidepressant effect of vortioxetine involves increased synaptic plasticity and promotion of spine maturation. Mitochondria dysfunction may contribute to the pathophysiological ... -
The current development of CNS drug research
Wegener, Gregers; Rujescu, Dan (Oxford Univ Press, 2013)In the past few years, several high profiled pharmaceutical companies have decided to shut down major research activities within the central nervous system (CNS) area. For example, in December 2011 Novartis announced ... -
Decreased in vivo α2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression
Landau, Anne M.; Wegener, Gregers; Phan, Jenny-Ann; Iversen, Peter; Lillethorup, Thea P. (Elsevier, 2015)Depression is a debilitating heterogenous disorder and the underlying mechanisms remain elusive. Alterations in monoaminergic neurotransmission, including noradrenergic, have been implicated in the etiology of depression. ... -
Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour
Winther, Gudrun; Wegener, Gregers; Jorgensen, Betina M. Pyndt; Elfving, Betina; Nielsen, Denis Sandris (Cambridge Univ Press, 2015)Objective: Gut microbiota (GM) has previously been associated with alterations in rodent behaviour, and since the GM is affected by the diet, the composition of the diet may be an important factor contributing to behavioural ... -
Differential expression of postsynaptic NMDA and AMPA receptor subunits in the hippocampus and prefrontal cortex of the flinders sensitive line rat model of depression
Treccani, Giulia; Wegener, Gregers; Du Jardin, Kristian Gaarn; Müller, Heidi Kaastrup (Wiley, 2016)Glutamatergic abnormalities have recently been implicated in the pathophysiology of depression, and the ionotropic glutamate receptors in particular have been suggested as possible underlying molecular determinants. The ... -
Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression
Du Jardin, Kristian Gaarn; Wegener, Gregers; Liebenberg, Nico; Müller, Heidi Kaastrup; Elfving, Betina (Springer, 2016)Rationale The mechanisms mediating ketamine’s antidepressant effect have only been partly resolved. Recent preclinical reports implicate serotonin (5-hydroxytryptamine; 5-HT) in the antidepressant-like action of ketamine. ... -
Discovery versus implementation research on mental disorders in low- and middle-income countries. Editorial
Stein, Dan J.; Wegener, Gregers (Cambridge Univ Press, 2017)The 10/90 research gap refers to the fact that only 10% of the world’s research resources are spent in lowand middle-income countries (LMICs) although 90% of preventable deaths occur in these regions: similar disparities ... -
A dual inhibitor of FAAH and TRPV1 channels shows dose-dependent effect on depression-like behaviour in rats
Kirkedal, Christian; Wegener, Gregers; Moreira, Fabricio; Joca, Samia Regiane Lourenco; Liebenberg, Nico (Cambridge Univ Press, 2017)Objective: The cannabinoid receptor 1 (CB1) and transient receptor potential cation channel subfamily V member 1 (TRPV1) are proposed to mediate opposite behavioural responses. Their common denominator is the endocannabinoid ... -
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
Fryland, Tue; Wegener, Gregers; Elfving, Betina; Christensen, Jane H.; Mors, Ole (Elsevier, 2012)Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment ... -
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
Fryland, Tue; Wegener, Gregers; Elfving, Betina; Christensen, Jane H.; Mors, Ole; Fryland, Tue; Wegener, Gregers; Elfving, Betina; Christensen, Jane H.; Mors, Ole (Elsevier, 2012)Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment ... -
Electroconvulsive shocks decrease α2-adrenoceptor binding in the Flinders rat model of depression
Lillethorup, Thea P.; Wegener, Gregers; Iversen, Peter; Fontain, Jesper; Doudet, Doris J. (Elsevier, 2015)Despite years of drug development, electroconvulsive therapy (ECT) remains the most effective treatment for severe depression. The exact therapeutic mechanism of action of ECT is still unresolved and therefore we tested ... -
Elevation of Il6 is associated with disturbed let-7 biogenesis in a genetic model of depression
Wei, Y.B.; Wegener, G.; Liu, J.J.; Villaescusa, J.C.; Åberg, E. (Springer Nature, 2016)Elevation of the proinflammatory cytokine IL-6 has been implicated in depression; however, the mechanisms remain elusive. MicroRNAs (miRNAs) are small non-coding RNAs that inhibit gene expression post-transcriptionally. ...