Browsing Faculty of Health Sciences@PUK by Subject "Animal model"

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Evidence for time-dependent interactions between Ritonavir and Lopinavir/Ritonavir plasma levels following P-Glycoprotein inhibition in Sprague-Dawley rats

Rheeders, Malie; Viljoen, Michelle; Du Plooy, Michael (Pharmaceutical Society of Japan, 2011)

The interaction between verapamil, a P-glycoprotein (P-gp) inhibitor, with ritonavir and lopinavir/ritonavir (LPV/r) after acute and chronic treatment was investigated in rats. Rats were divided into 4 groups, viz. Group ...