Browsing Faculty of Health Sciences by Subject "Bioavailability"
Now showing items 1-4 of 4
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Beneficial pharmacokinetic drug interactions: a tool to improve the bioavailability of poorly permeable drugs
(MDPI, 2018)Simultaneous oral intake of herbs, supplements, foods and drugs with other drug(s) may result in pharmacokinetic or pharmacodynamic interactions with the latter. Although these interactions are often associated with unwanted ... -
In vivo efficacy and bioavailability of lumefantrine: evaluating the application of Pheroid technology
(Elsevier, 2015)The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic absorption and highly variable ... -
Modeling nanoparticle delivery of TB drugs to granulomas
(Elsevier, 2016)Tuberculosis, which typically presents as a pulmonary disease, has a complex pathology. The primary site of infection, the Ghon focus, recruits immune cells and a granuloma forms. At earlier stages the granuloma is still ... -
The role of functional excipients in solid oral dosage forms to overcome poor drug dissolution and bioavailability
(MDPI, 2020)Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The oral bioavailability of these compounds ...