Browsing Faculty of Health Sciences by Subject "Cancer"
Now showing items 1-10 of 10
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Benzopyrone represents a privilege scaffold to identify novel adenosine A1/A2A receptor antagonists
(Elsevier, 2018)Adenosine receptor antagonists are under investigation as potential drug candidates for the treatment of certain cancers, neurological disorders, depression and potentially improve tumour immunotherapy. The benzo-γ-pyrone ... -
A comparison between selected noncommunicable disease mortality rates between 2010 and 2016 among selected Southern African countries
(Sage, 2020)Researchers have identified cancer, diabetes mellitus, cardiovascular, and respiratory diseases as being the principal pathologies of increased aged standardized death rates (ASDRs) among noncommunicable diseases (NCDs). ... -
The development of a value based pricing index for new drugs in metastatic colorectal cancer
(Elsevier, 2011)Background Worldwide, prices for cancer drugs have been under downward pressure where several governments have mandated price cuts of branded products. A better alternative to government mandated price cuts would be to ... -
Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro
(Elsevier, 2017)In the Krebs cycle, succinate is oxidized to fumarate by succinate dehydrogenase (SDH), followed by the conversion of fumarate to malate by fumarate hydratase (FH). In cells with defective SDH and FH, the Krebs cycle is ... -
Indirect implications of COVID-19 prevention strategies on non-communicable diseases: an opinion paper of the European Society of Hypertension Working Group on Hypertension and Cardiovascular Risk Assessment in subjects living in or emigrating from low resource settings
(BMC, 2020)Background After its outbreak in China, the novel COronaVIrus Disease 19 is spreading across the globe. It is an emergency the world has never seen before. Main text The attention of health systems is mainly focused ... -
Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: a multinational cohort study
(BioMed Central, 2020)Background Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely ... -
Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux
(Springer, 2019)Purpose Efflux transporters of the adenosine triphosphate-binding cassette (ABC)-superfamily play an important role in the development of multidrug resistance (multidrug resistant; MDR) in cancer. The overexpression of ... -
Patient-family communication mediates the relation between family hardiness and caregiver positivity: exploring the moderating role of caregiver depression and anxiety
(Taylor & Francis, 2019)Purpose: Despite the theoretical and empirical significance of positive aspects of caregiving in caregiver well-being, relatively little is known regarding family-related predictors of caregiver positivity. This study ... -
Reference gene selection for in vitro cell-free DNA analysis and gene expression profiling
(Elsevier, 2016)Objectives: (i) To optimize cell-free DNA (cfDNA) and mRNA quantification using eight housekeeping genes (HKGs), (ii) to determine if there is a difference in the occurrence of HKGs in the cfDNA andmRNA of normal cells and ... -
Synthesis and biological evaluation of a series of non-hemiacetal ester derivatives of artemisinin
(Elsevier, 2016)In an attempt to improve the efficacy and stability of current, clinically used artemisinins, a series non-hemiacetal ester derivatives of artemisinin were synthesized and evaluated for their in vitro antiplasmodial and ...