Browsing Faculty of Health Sciences@PUK by Author "Castagnoli, Neal"
Dual-Target-Directed Drugs that Block Monoamne Oxidase B and Adenosine A2A Receptors for Parkiinson's Disease Petzer, Jacobus; Castagnoli, Neal; Schwarzschild, Michael A; Chen,Jiang -Fan; Van der Schyf, Cornelis J (Springer, 2009)Inadequacies of the current pharmacotherapies to treat Parkinson's disease (PD) have prompted efforts to identify novel drug targets. The adenosine A2A receptor is one such target. Antagonists of this receptor (A2A ...
Strydom, Belinda; Malan, Sarel F.; Bergh, Jacobus J.; Petzer, Jacobus P.; Castagnoli, Neal (Elsevier, 2010)Based on recent reports that several (E)-8-styrylcaffeinyl analogues are potent reversible inhibitors of monoamine oxidase B (MAO-B), a series of 8-benzyloxycaffeinyl analogues were synthesized and evaluated as inhibitors ...
Structure-activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles Bergh, Jacobus J; Malan, Sarel F; Terre'Blanche, Gisella; Petzer, Jacobus P; Ogunrombi, Modupe O; Castagnoli, Neal (Elsevier Ltd, 2008)