Now showing items 1-5 of 5

    • Inhibition of monoamine oxidase by selected C6-substituted chromone derivatives 

      Legoabe, Lesetja J.; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2012)
      Chromone has been reported to be a useful scaffold for the design of monoamine oxidase (MAO) inhibitors. In an attempt to discover highly potent MAO inhibitors and to contribute to the known structureeactivity relationships ...
    • Selected C7-substituted chromone derivatives as monoamine oxidase inhibitors 

      Legoabe, Lesetja J.; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2012)
      A series of C7-substituted chromone (1-benzopyran-4-one) derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The chromones are structurally related to a series of ...
    • Selected chromone derivatives as inhibitors of monoamine oxidase 

      Legoabe, Lesetja J.; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2012)
      A previous study has shown that a series of C6-benzyloxy substituted chromones exhibit high binding affinities for human monoamine oxidase (MAO) B. In an attempt to discover additional chromones with potent and selective ...
    • Structural exploration of synthetic chromones as selective MAO-B inhibitors: a mini review 

      Mathew, Bijo; Petzer, Jacobus P.; Petzer, Anél; Mathew, Githa Elizabeth (Bentham Science, 2017)
      Aim and Objective: Specific inhibitors of monoamine oxidase (MAO)-B are considered useful therapeutic agents in targeting neurological disorders like Alzheimer's and Parkinson's diseases. Due to the academic challenge of ...
    • Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase 

      Mpitimpiti, Annah N.; Petzer, Jacobus P.; Petzer, Anél; Jordaan, Johannes H.L.; Lourens, Anna C.U. (Springer, 2019)
      Based on reports that chromone compounds are good potency inhibitors of monoamine oxidase (MAO), the present study evaluates the effect of substitution with flexible side chains on the 3 position on MAO inhibition potency. ...