Browsing Faculty of Health Sciences by Author "Cloete, Theunis T."
Now showing items 1-6 of 6
-
Antimalarial activity of 10-alkyl/aryl esters and – aminoethylethers of artemisinin
Cloete, Theunis T.; N’Da, David D.; Krebs, Henk J.; Clark, Julie A.; Connelly, Michele C. (Elsevier, 2013)A series of n-alkyl/aryl esters were synthesized and their in vitro antiplasmodial activity was measured alongside that of previously synthesized aminoethylethers of artemisinin ozonides against various strains of ... -
Methylene blue analogues: in vitro antimicrobial minimum inhibitory concentrations and in silico pharmacophore modelling
Thesnaar, Louis; Bezuidenhout, Jaco J.; Petzer, Anél; Petzer, Jacobus P.; Cloete, Theunis T. (Elsevier, 2020)It has been shown that methylene blue has antimicrobial properties although few studies have determined its minimum inhibitory concentration (MIC), which is the gold standard used to measure antimicrobial activity. The ... -
Mono-, di- and trisubstituted derivatives of eflornithine: synthesis for in vivo delivery of DL-alpha-difluoromethylornithine in plasma
Cloete, Theunis T.; N'Da, David D.; Breytenbach, Jaco C.; Johansson, Carl C.; Kumar Vodnala, Suman (Thieme, 2011)The aim of this study was to synthesize a series of mono-, di- and trisubstituted derivatives of the human African trypanosomiasis drug eflornithine (alpha-difluoromethylornithine, DMFO, CAS 70052-12-9) to determine their ... -
Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
Van Heerden, Lezanne; Cloete, Theunis T.; Breytenbach, J. Wilma; Breytenbach, Jaco C.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2012)Series of bisquinolines 4e15 and bispyrrolo[1,2a]quinoxalines 16e20 containing various polyamine linkers were synthesized. The aqueous solubility and distribution coefficient were experimentally determined. The compounds ... -
Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin
Cloete, Theunis T.; Breytenbach, J. Wilma; Breytenbach, Jaco C.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2012)In this study, a series of 11 10-aminoethylether derivatives of artemisinin were synthesised and their antimalarial activity against both the chloroquine sensitive (D10) and resistant (Dd2) strains of Plasmodium falciparum ... -
Synthesis, in vitro antiplasmodial activity and cytotoxicity of a series of artemisininetriazine hybrids and hybrid-dimers
Cloete, Theunis T.; N'Da, David D.; De Kock, Carmen; Smith, Peter J. (Elsevier, 2014)A series of artemisininetriazine hybrids and hybrid-dimers were synthesized and their in vitro antimalarial activity against the chloroquine sensitive (CQS), the gametocytocidal (NF54) and the choroquine resistant (CQR) ...