Browsing Faculty of Health Sciences by Author "Conradie, Karin R."
Now showing items 1-3 of 3
-
C679X loss-of-function PCSK9 variant lowers fasting glucose levels in a black South African population: a longitudinal study
Chikowore, Tinashe; Cockeran, Marike; Conradie, Karin R.; Van Zyl, Tertia (Elsevier, 2018)Aims To determine the longitudinal association of the loss-of-function (LOF) PCSK9 variants (C679X and A443T), proxies of PCSK9 inhibitor drugs, with LDL-C, fasting glucose and glycated hemoglobin. Methods We conducted ... -
Common and rare single nucleotide polymorphisms in the LDLR gene are present in a black South African population and associate with low-density lipoprotein cholesterol levels
Van Zyl, Tertia; Jerling, Johann C.; Conradie, Karin R.; Feskens, Edith J.M. (Nature Publishing Group, 2014)The LDL receptor has an essential role in regulating plasma LDL-C levels. Genetic variation in the LDLR gene can be associated with either lower or moderately raised plasma levels of LDL-C, or may cause familial ... -
In black South Africans from rural and urban communities, the 4G/5G PAI–1 polymorphism influences PAI–1 activity, but not plasma clot lysis time
De Lange, Zelda; Conradie, Karin R.; Jerling, Johann C.; Pieters, Marlien; Rijken, Dingeman C.; Hoekstra, T. (Public Library of Science, 2013)Data on genetic and environmental factors influencing PAI-1 levels and their consequent effect on clot lysis in black African populations are limited. We identified polymorphisms in the promoter area of the PAI-1 gene and ...