Browsing Faculty of Health Sciences by Author "Gerber, M."
Now showing items 1-6 of 6
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Development and validation of the simultaneous determination of artemisone, clofazimine and decoquinate with HPLC
Du Preez, J.L.; Aucamp, M.E.; Burger, C.; Gerber, M.; Viljoen, J.M.; Van Zyl, L.; Du Plessis, J. (Avoxa, 2018)The aim of this study was to develop and validate a novel HPLC method for the simultaneous analysis of artemisone, clofazimine and decoquinate. Detection was obtained at two wavelengths; 284 nm (clofazimine) and 210 nm ... -
Exploratory data analysis of the dependencies between skin permeability, molecular weight and log P
Kilian, D.; Lemmer, H.J.R.; Gerber, M.; Du Preez, J.L.; Du Plessis, J. (Govi-Verlag, 2016)Molecular weight and log P remain the most frequently used physicochemical properties in models that predict skin permeability. However, several reports over the past two decades have suggested that predictions made by ... -
Formulation and transdermal delivery of aciclovir and ketoconazole for HIV/AIDS patients
Jacobs, G.A.; Gerber, M.; Malan, M.M.; Du Preez, J.; Du Plessis, J. (Wiley, 2010)Due to their compromised immune systems, HIV/ AIDS- infected individuals are more susceptible to skin infections. Since fungal and viral cutaneous manifestations are frequently encountered in combination in HIV/AIDS patients, ... -
A novel RP-HPLC method for the detection and quantification of roxithromycin in topical delivery studies
Aucamp, M.E.; Csongradi, C.; Gerber, M.; Du Plessis, J. (Govi-Verlag, 2015)A novel HPLC method with UV detection for the identification and quantification of roxithromycin (ROX) during in vitro skin penetration studies has been developed and validated. The method proved to be simple and rapid ... -
Topical and transdermal delivery of L-carnitine
Fox, L.T.; Gerber, M.; Grobler, A.; Du Preez, J.L.; Du Plessis, J. (Karger, 2011)Background: The two types of skin aging (intrinsic and extrinsic) share important molecular features, while having distinct differences on the macromolecular level: both lead to increased production of reactive oxygen ... -
Topical delivery of selected growth factors
Van Niekerk, L.; Campell, B.; Gerber, M.; Du Plessis, L.H.; Du Plessis, J. (Wiley, 2010)Growth factors can benefit from controlled release admin- istration technologies (i.e. topical or transdermal delivery). When compared with other epithelial membranes, the skin has less enzymatic activity and so provides ...