Browsing Faculty of Health Sciences@PUK by Author "Gravestock, David"
Expeditious synthesis and biological evaluation of novel 2,N6-disubstituted 1,2 dihydro-1,3,5-triazine-4,6-diamines as potential antimalarials Gravestock, David; Rousseau, Amanda L.; Lourens, Anna Catharina U.; Moleele, Simon S.; Van Zyl, Robyn L.; Steenkamp, Paul A. (2011)A small set of novel 2,N6-disubstituted 1,2-dihydro-1,3,5-triazine-4,6-diamines was prepared possessing a flexible tether between the exocyclic nitrogen bonded to C-6 of the 1,2-dihydro-1,3,5-triazine-4,6-diamine heterocycle ...
Novel branched isocyanides as useful building blocks in the Passerini–amine deprotection–acyl migration (PADAM) synthesis of potential HIV–1 protease inhibitors Gravestock, David; Lourens, Anna C.U.; Rousseau, Amanda L.; Hoppe, Heinrich C.; Nkabinde, Lindiwe A.; Bode, Moira L. (Elsevier, 2012)Novel branched isocyanides have been prepared from L-serine and used as building blocks in the Passerini- amine deprotection-acyl migration (PADAM) sequence for the preparation of compounds with activity against HIV-1 protease