Browsing Faculty of Health Sciences by Author "Grobler, Anne F."
Now showing items 1-11 of 11
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Absorption of the novel artemisinin derivatives artemisone and artemiside: potential application of Pheroid™ technology
Steyn, J. Dewald; Du Plessis, Lissinda H.; Grobler, Anne F.; Kotzé, Awie F.; Haynes, Richard K. (Elsevier, 2011)Artemisinins have low aqueous solubility that results in poor and erratic absorption upon oral administration. The poor solubility and erratic absorption usually translate to low bioavailability. Artemisinin-based monotherapy ... -
Advances in GBA-associated Parkinson's disease: pathology, presentation and therapies
Barkhuizen, Melinda; Grobler, Anne F.; Anderson, David G. (Elsevier, 2016)GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The GBA gene encodes the lysomal hydrolase glucocerebrosidase. Whilst bi-allelic GBA mutations cause Gaucher disease, both mono- and ... -
Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro
Grobler, Lizette; Haynes, Richard K.; Grobler, Anne F.; Chavchich, Marina; Edstein, Michael D. (American Society for Microbiology, 2014)The in vitro antimalarial activities of artemisone and artemisone entrapped in Pheroid vesicles were compared, as was their ability to induce dormancy in Plasmodium falciparum. There was no increase in the activity of ... -
Chemical composition, but not specific surface area, affects calcium retention of nanostructured calcium compounds in growing rats
Posavec, Lidija; Baumgartner, Jeannine; Buntting, Hylton; Grobler, Anne F.; Hilty, Florentine M. (Oxford Univ Press, 2017)Background: Low dietary calcium intake and bioavailability may adversely affect bone health. Reducing the size of calcium compounds increases their specific surface area (SSA, expressed as m2/g) and may increase calcium ... -
Comparing antibody responses in chickens against Plasmodium falciparum lactate dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase with Freund’s and Pheroid® adjuvants
Krause, Robert G.E.; Grobler, Anne F.; Goldring, J.P. Dean (Taylor & Francis, 2015)Pheroid® technology was assessed as an alternative to Freund’s adjuvant to raise antibodies in experimental animals. Chickens were immunized with two recombinantly expressed Plasmodium falciparum proteins, lactate dehydrogenase ... -
Influence of variation in eumelanin content on absorbance spectra of liquid skin-like phantoms
Smit, Jacoba E.; Grobler, Anne F.; Sparrow, Raymond W. (Wiley, 2011)The attenuation behavior of two different types of skin-like phantoms representing the range of Fitzpatrick skin Types I–VI was investigated and compared with real human skin. Intralipid (IL) and Pheroid™ artificial lipid ... -
A molecular analysis of the GBA gene in Caucasian South Africans with Parkinson's disease
Barkhuizen, Melinda; Van der Westhuizen, Francois H.; Grobler, Anne F.; Anderson, David G. (Wiley, 2017)Background The molecular basis of Parkinson's disease in South African population groups remains elusive. To date, substitutions in the GBA gene are the most common large-effect genetic risk factor for Parkinson's disease. ... -
The safety and efficacy of Meriva (R) and ginger extract combination in Pheroid (R) against lung cancer
Bekele, Bisrat; Pheiffer, Wihan; Grobler, Anne F. (Elsevier, 2020)Lung cancer is the leading cause of cancer related deaths, globally, with poor survival profile. Cisplatin is frequently used in the treatment of many solid tumors including lung cancer despite its toxicity; ototoxicity, ... -
Trends in malaria admissions at the Mbakong Health Centre of the North West Region of Cameroon: a retrospective study
Cheng, Ndong Ignatius; Van Reenen, Mari; Grobler, Anne F.; Boakye, Daniel A.; Mbacham, Wilfred F. (BioMed Central, 2014)Background: Malaria is the leading cause of death worldwide. It is urgent to assess the impact of interventions and scaled-up control efforts. Despite reported reduction in malaria prevalence in Africa, the trends in ... -
Trends in malaria case management following changes in the treatment policy to artemisinin combination therapy at the Mbakong Health Centre, Cameroon 2006-2012: a retrospective study
Cheng, Ndong Ignatius; Van Reenen, Mari; Grobler, Anne F.; Boakye, Daniel A. (Elsevier, 2015)National malaria treatment policies are devised to guide health professionals and to facilitate diagnosis and case management. Following the recommendations of the WHO, Cameroon changed its malaria treatment policy from ... -
The use of cytokines and oxidative stress markers as indicators for drug safety
Griessel, Helene; Pheiffer, Wihan; Jansen van Rensburg, Emile; Zeevaart, Jan Rijn; Grobler, Anne F. (Elsevier, 2020)Safety and efficacy are of concern in developing new compounds. There is a paucity on the changes made by new compounds on inflammatory cytokines in combination with oxidative stress markers. Cytokines are potential markers ...