Now showing items 1-8 of 8

    • Eudragit® L100/N-trimethylchitosan chloride microspheres for oral insulin delivery 

      Marais, Etienne; Hamman, Josias; Du Plessis, Lissinda; Lemmer, Righard; Steenekamp, Jan (MDPI, 2013)
      Effective oral delivery of protein and peptide drugs remains an active topic in scientific research. In this study, matrix type microspheres were prepared with Eudragit® L100 containing N-trimethylchitosan chloride to ...
    • Excipients with specialized functions for effective drug delivery 

      Hamman, Josias; Steenekamp, Jan (Taylor & Francis, 2012)
      Introduction: There is a growing need for the development of pharmaceutical excipients that could improve product performance and overcome the shortcomings of new drug moieties, such as their poor solubility and membrane ...
    • In vitro drug absorption enhancement effects of Aloe vera and Aloe ferox 

      Beneke, Catharina; Hamman, Josias; Viljoen, Alvaro (Österreichische Apotheker-Verlagsgesellschaft, 2012)
      The effect of whole leaf and gel materials from two aloe species (Aloe vera and A. ferox) was compared with that of the precipitated polysaccharides from these aloe materials on the transepithelial electrical resistance ...
    • In vitro drug permeation enhancement potential of aloe gel materials 

      Lebitsa, Tebogo; Hamman, Josias; Lu, Zhilei; Viljoen, Alvaro (Bentham Science, 2012)
      Aloe vera gel previously showed the ability to increase the bioavailability of vitamins and to enhance the in vitro transport of a macromolecular drug across intestinal epithelial cell monolayers. The purpose of this study ...
    • Modulation of drug efflux by aloe materials: an in vitro investigation across rat intestinal tissue 

      Beneke, Carien; Hamman, Josias; Viljoen, Alvaro (Wolters Kluwer-Medknow, 2013)
      Background: Clinically, significant herb-drug interactions have been previously documented and can be pharmacodynamic and/or pharmacokinetic in nature. Pharmacokinetic interactions have been attributed to induction or ...
    • More good news about polymeric plant- and algae-derived biomaterials in drug delivery systems 

      Scholtz, Jacques; Van der Colff, Jaco; Steenekamp, Jan; Stieger, Nicole; Hamman, Josias (Bentham Science, 2014)
      Natural polymers are continuously investigated for use in pharmaceutical and tissue engineering applications due to the renewability of their supply. Besides the conventional use of natural materials in dosage form design ...
    • Novel non-invasive protein and peptide drug delivery approaches 

      Wallis, Lonette; Kleynhans, Elmarie; Du Toit, Trizel; Gouws, Chrisna; Steyn, Dewald; Steenekamp, Jan; Viljoen, Joe; Hamman, Josias (Bentham Science, 2014)
      Protein and peptide based therapeutics are typically administered by injection due to their poor uptake when administered via enteral routes of drug administration. Unfortunately, chronic administration of these drugs ...
    • Transport of aspalathin, a rooibos tea flavonoid, across the skin and intestinal epithelium 

      Huang, Miao; Du Plessis, Jeanetta; Du Preez, Jan; Hamman, Josias; Viljoen, Alvaro (Wiley, 2008)
      Since Rooibos tea contains high levels of flavonoid antioxidants with potential health benefits when taken orally or applied topically, the quantity of the antioxidants crossing the physiological barriers is of scientific, ...