Now showing items 1-2 of 2

    • Inhibition of monoamine oxidase by C5-substituted phthalimide analogues 

      Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Manley-King, Clarina Ilara (Elsevier, 2011)
      Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced ...
    • Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B 

      Petzer, Jacobus Petrus; Petzer, Anél; Terre'Blanche, Gisella; Van der Walt, Mietha Magdalena (Elsevier, 2012)
      Monoamine oxidase (MAO) plays an essential role in the catabolism of neurotransmitter amines. The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative ...