Browsing Faculty of Health Sciences by Subject "Isatin"
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Inhibition of monoamine oxidase by C5-substituted phthalimide analogues
(Elsevier, 2011)Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced binding ... -
Inhibition of monoamine oxidase by E-styrylisatin analogues
(Elsevier, 2009)Previous studies have shown that (E)-8-(3-chlorostyryl)caffeine (CSC) is a specific reversible inhibitor of human monoamine oxidase B (MAO-B) and does not bind to human MAO-A. Since the small molecule isatin is a natural ... -
Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B
(Elsevier, 2012)Monoamine oxidase (MAO) plays an essential role in the catabolism of neurotransmitter amines. The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative ...