Browsing Faculty of Health Sciences by Subject "Phthalimide"
Now showing items 1-3 of 3
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Inhibition of monoamine oxidase by C5-substituted phthalimide analogues
(Elsevier, 2011)Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced binding ... -
Monoamine oxidase inhibition by C4-substituted phthalonitriles
(Elsevier, 2012)It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms ... -
Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B
(Elsevier, 2012)Monoamine oxidase (MAO) plays an essential role in the catabolism of neurotransmitter amines. The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative ...