Browsing Faculty of Health Sciences by Author "Stieger, Nicole"
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Channel inclusion of primary alcohols in isostructural solvates of the antiretroviral nevirapine: an X-ray and thermal analysis study
Stieger, Nicole; Liebenberg, Wilna; Wessels, Johanna C.; Samsodien, Halima; Caira, Mino R. (Springer, 2010)X-ray structural and thermoanalytical data for a series of solvates 2–7 of the anti-HIV drug nevirapine containing primary alcohols CH3(CH2)nOH with n = 2–7 are reported. The structures of 2–7 are based on a common ... -
Co-crystals of the antiretroviral nevirapine: crystal structures, thermal analysis and dissolution behaviour
Caira, Mino R.; Liebenberg, Wilna; Stieger, Nicole; Aucamp, Marique; Bourne, Susan A. (RSC, 2012)Synthesis and physicochemical characterization of co-crystals of the antiretroviral drug nevirapine (NV) with the pharmaceutically acceptable co-formers saccharin, rac-tartaric acid, maleic acid, glutaric acid and salicylic ... -
Influence of the composition of water/ethanol mixtures on the solubility and recrystallization of nevirapine
Stieger, Nicole; Liebenberg, Wilna; Tiedt, Louwrens R.; Wessels, Johanna C.; Caira, Mino R. (ACS, 2010)Anhydrous nevirapine was recrystallized from ethanol containing various amounts of water to determine its effects on the products obtained. The solubility of the anhydrous form was determined for each of the binary solvent ... -
Inulin suitable as reduced-kilojoule carrier for production of microencapsulated spray-dried green Cyclopia subternata (honeybush) extract
Pauck, Claire; Aucamp, Marique; Liebenberg, Wilna; Stieger, Nicole; De Beer, Dalene (Elsevier, 2017)Retention of phenolic compounds during spray-drying of an anti-diabetic C. subternata extract and physicochemical characteristics of spray-dried powders (pure extract and extract-carrier mixtures) were evaluated. Extract-carrier ... -
More good news about polymeric plant- and algae-derived biomaterials in drug delivery systems
Scholtz, Jacques; Van der Colff, Jaco; Steenekamp, Jan; Stieger, Nicole; Hamman, Josias (Bentham Science, 2014)Natural polymers are continuously investigated for use in pharmaceutical and tissue engineering applications due to the renewability of their supply. Besides the conventional use of natural materials in dosage form design ... -
Phenolic and physicochemical stability of a functional beverage powder mixture during storage: effect of the microencapsulant inulin and food ingredients
De Beer, Dalene; Aucamp, Marique; Liebenberg, Wilna; Stieger, Nicole; Pauck, Claire E. (Wiley, 2018)BACKGROUND The need for a convenience herbal iced tea product with reduced kilojoules merited investigation of the shelf-life of powder mixtures containing a green Cyclopia subternata Vogel (honeybush) extract with proven ... -
Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles
Strydom, Schalk J.; Otto, Daniel P.; Stieger, Nicole; Aucamp, Marique E.; Liebenberg, Wilna (Elsevier, 2014)A layer-by-layer (LbL) nanocoat (b25 nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method ... -
Solution-mediated phase transformation of different roxithromycin solid-state forms: implications on dissolution and solubility
Aucamp, Marique; Stieger, Nicole; Barnard, Neil; Liebenberg, Wilna (Elsevier, 2013)The objective of this study was to describe the solid-state forms in which roxithromycin may exist and the significant influence of solution-mediated phase transformation on the dissolution and solubility behavior of ... -
Solvatomorphism of the antibacterial dapsone: X-ray structures and thermal desolvation kinetics
Lemmer, Helanie; Stieger, Nicole; Liebenberg, Wilna; Caira, Mino R. (ACS, 2012)Three non-isostructural solvates of the antibacterial dapsone (DDS) containing dichloromethane [DDS•0.5(DCM)], 1,4-dioxane [DDS•DXN], and tetrahydrofuran [DDS•THF] were prepared and characterized by X-ray diffraction (XRD) ... -
Solvent inclusion by the anti-HIV drug nevirapine: X-ray structures and thermal decomposition of representative solvates
Caira, Mino R.; Stieger, Nicole; Liebenberg, Wilna; De Villiers, Melgardt M.; Samsodien, Halima (ACS, 2008)Five crystalline solvates of the anti-HIV drug Nevirapine (N), with compositions N·(ethyl acetate)0.5 (1), N·(dichloromethane)0.5 (2), N·(toluene)0.5 (3), N·(water)0.5 (4), and N·(1,4-dioxane)1.5 (5), were isolated and ...