Now showing items 1-8 of 8

    • Deuterium isotope effects for the oxidation of 1-methyl-3phenyl-3pyrrolinyl analogues by monoamine oxidase B 

      Pretorius, Anél; Ogunrombi, Modupe O.; Terre'Blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P.; Pretorius, Anél; Ogunrombi, Modupe O.; Terre'Blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2008)
      The parkinsonian inducing agent, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), is a cyclic tertiary allylamine exhibiting good monoamine oxidase B (MAO-B) substrate properties. MAO-B catalyzes the ring α-carbon ...
    • Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B 

      Van der Walt, Mietha M.; Terre'Blanche, Gisella; Petzer, Anél; Petzer, Jacobus P.; Van der Walt, Mietha M.; Terre'Blanche, Gisella; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2012)
      Monoamine oxidase (MAO) plays an essential role in the catabolism of neurotransmitter amines. The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative ...
    • Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate 

      Viljoen, Jacques; Bergh, Jacobus J.; Mienie, Lodewyk J.; Terre'Blanche, Gisella; Kotze, Hercullas F.; Viljoen, Jacques; Bergh, Jacobus J.; Mienie, Lodewyk J.; Terre'Blanche, Gisella; Kotze, Hercullas F. (Springer, 2012)
      Valproate administration increases the level of the inhibitory transmitter, glycine, in the urine and plasma of patients and experimental animals. Nonketotic hyperglycinemia (NKH), an autosomal recessive disorder of ...
    • Structure-activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles 

      Ogunrombi, Modupe O.; Malan, Sarel F.; Terre'Blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P.; Ogunrombi, Modupe O.; Malan, Sarel F.; Terre'Blanche, Gisella; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2008)
      1-Methyl-3-phenyl-3-pyrrolines are structural analogues of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and like MPTP are selective substrates of monoamine oxidase B (MAO-B). As part of an ongoing ...
    • The styrene metabolite, phenylglyoxylic acid, induces striatal-motor toxicity in the rat: influence of dose escalation/reduction over time 

      Terre'Blanche, Gisella; Heyer, Nicolette; Bergh, Jacobus J.; Mienie, Lodewyk J.; Harvey, Brian H.; Van der Schyf, Cornelius J.; Terre'Blanche, Gisella; Heyer, Nicolette; Bergh, Jacobus J.; Mienie, Lodewyk J.; Harvey, Brian H.; Van der Schyf, Cornelius J. (Springer, 2011)
      Exposure to the industrial solvent, styrene, induces locomotor and cognitive dysfunction in rats, and parkinsonian-like manifestations in man. The antipsychotic, haloperidol (HP), well known to induce striatal toxicity in ...
    • Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B 

      Van der Walt, Mietha M.; Terre'Blanche, Gisella; Lourens, Anna C.U.; Petzer, Anél; Petzer, Jacobus P.; Van der Walt, Mietha M.; Terre'Blanche, Gisella; Lourens, Anna C.U.; Petzer, Anél; Petzer, Jacobus P. (Elsevier, 2012)
      It has recently been reported that nitrile containing compounds frequently act as potent monoamine oxidase B (MAO-B) inhibitors. Modelling studies suggest that this high potency inhibition may rely, at least in part, on ...
    • Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase 

      Booysen, Hermanus P.; Moraal, Christina; Terre'Blanche, Gisella; Petzer, Anél; Bergh, Jacobus J.; Petzer, Jacobus P.; Booysen, Hermanus P.; Moraal, Christina; Terre'Blanche, Gisella; Petzer, Anél; Bergh, Jacobus J.; Petzer, Jacobus P. (Elsevier, 2011)
      In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for ...
    • Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid: a case report 

      Terre'Blanche, Gisella; Van der Walt, Mietha M.; Bergh, Jacobus J.; Mienie, Lodewyk J.; Terre'Blanche, Gisella; Van der Walt, Mietha M.; Bergh, Jacobus J.; Mienie, Lodewyk J. (BioMed Central, 2011)
      This is a case report of adrenomyeloneuropathy (AMN), the adult variant of adrenoleukodystryphy (ALD). The diagnoses in the patient, aged 34, was confirmed via increased serum very long chain fatty acid concentration (VLCFA). ...