Now showing items 1-6 of 6

    • 8-Aryl- and alkyloxycaffeine analogues as inhibitors of monoamine oxidase 

      Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Strydom, Belinda (Elsevier, 2011)
      Recently it was reported that a series of 8-benzyloxycaffeine analogues are potent reversible inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to discover additional C8 oxy substituents of caffeine that ...
    • The inhibition of monoamine oxidase by 8-(2-phenoxyethoxy) caffeine analogues 

      Strydom, Belinda; Bergh, Jacobus Johannes; Petzer, Jacobus Petrus (Thieme, 2012)
      Previous studies have documented that substituted 8-oxycaffeines act as inhibitors of human monoamine oxidase (MAO) B. A particularly potent inhibitor among the reported compounds was 8-(2-phenoxyethoxy)caffeine with an ...
    • Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues 

      Bergh, Jacobus Johannes; Mentz, Wayne; Mostert, Samantha; Petzer, Jacobus Petrus; Petzer, Anél (Elsevier, 2012)
      In a previous study we have investigated the monoamine oxidase (MAO) inhibitory properties of a series of 8-sulfanylcaffeine analogues. Among the compounds studied, 8-[(phenylethyl)sulfanyl]caffeine (IC50 = 0.223 lM) was ...
    • Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues 

      Strydom, Belinda; Malan, Sarel F.; Bergh, Jacobus J.; Petzer, Jacobus P.; Castagnoli, Neal (Elsevier, 2010)
      Based on recent reports that several (E)-8-styrylcaffeinyl analogues are potent reversible inhibitors of monoamine oxidase B (MAO-B), a series of 8-benzyloxycaffeinyl analogues were synthesized and evaluated as inhibitors ...
    • Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives 

      Bergh, Jacobus Johannes; Okaecwe, Thokozile Audrey Dorcas; Petzer, Jacobus Petrus; Swanepoel, Abraham Johannes; Petzer, Anél (Elsevier, 2012)
      A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...
    • Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase 

      Bergh, Jacobus Johannes; Booysen, Hermanus Perold; Moraal, Christina Maria; Petzer, Jacobus Petrus; Petzer, Anél; Terre'Blanche, Gisella (Elsevier, 2011)
      In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for ...