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Browsing Faculty of Health Sciences@PUK by Subject "malaria"

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Browsing Faculty of Health Sciences@PUK by Subject "malaria"

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  • Breytenbach, Jaco Cornelius; Meredith, Sandra; Smith, Peter; Steyn, Minette; N'Da, David Dago; Breytenbach, Wilhelmina Johanna (Wiley, 2011)
    Objectives The aim of this study was to synthesize a series of ethylene glycol ether derivatives of the antimalarial drug artemisinin, determine their values for selected physicochemical properties and evaluate their ...
  • Breytenbach, Jaco Cornelius; Breytenbach, Johanna Wilhelmina; Cloete, Theunis Theodorus; N'da, David Dago; Smith, Peter; De Kock, Carmen (Elsevier, 2012)
    In this study, a series of 11 10-aminoethylether derivatives of artemisinin were synthesised and their antimalarial activity against both the chloroquine sensitive (D10) and resistant (Dd2) strains of Plasmodium falciparum ...
  • Breytenbach, Jaco Cornelius; Lombard, Martha Carolina; N'da, David Dago; Lategan, Carmen A.; Smith, Peter J. (Elsevier, 2011)
    Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids 9–14, which were then treated with oxalic acid to form oxalate salts (9a–14a). Compounds 9a, 10a, 12, 12a, and 14a showed comparable ...

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