Browsing Faculty of Health Sciences@PUK by Subject "malaria"

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Browsing Faculty of Health Sciences@PUK by Subject "malaria"

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  • Du Plessis, Lissinda H.; Helena, Chrizaan; Van Huysteen, Este; Kotzé, Awie F.; Wiesner, Lubbe (Wiley-Blackwell on behalf of Royal Pharmaceutical Society, 2014)
    Objectives Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the treatment and chemoprophylaxis of malaria. However, it has low solubility in water, a long elimination half-life (4 days), and is ...
  • Du Plessis, Lissinda H.; Van Niekerk, Anel C.; Maritz, Marlene M.; Kotzé, Awie F. (Nature Publishing Group, 2012)
    The macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been demonstrated. In this study, we investigated the enhancement of the ...
  • Breytenbach, Jaco Cornelius; Meredith, Sandra; Smith, Peter; Steyn, Minette; N'Da, David Dago; Breytenbach, Wilhelmina Johanna (Wiley, 2011)
    Objectives The aim of this study was to synthesize a series of ethylene glycol ether derivatives of the antimalarial drug artemisinin, determine their values for selected physicochemical properties and evaluate their ...
  • Breytenbach, Jaco Cornelius; Breytenbach, Johanna Wilhelmina; Cloete, Theunis Theodorus; N'da, David Dago; Smith, Peter; De Kock, Carmen (Elsevier, 2012)
    In this study, a series of 11 10-aminoethylether derivatives of artemisinin were synthesised and their antimalarial activity against both the chloroquine sensitive (D10) and resistant (Dd2) strains of Plasmodium falciparum ...
  • Breytenbach, Jaco Cornelius; Lombard, Martha Carolina; N'da, David Dago; Lategan, Carmen A.; Smith, Peter J. (Elsevier, 2011)
    Dihydroartemisinin (DHA) was coupled to different aminoquinoline moieties forming hybrids 9–14, which were then treated with oxalic acid to form oxalate salts (9a–14a). Compounds 9a, 10a, 12, 12a, and 14a showed comparable ...

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