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Browsing Faculty of Health Sciences@PUK by Subject "reversible inhibition"

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Browsing Faculty of Health Sciences@PUK by Subject "reversible inhibition"

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  • Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Strydom, Belinda (Elsevier, 2011)
    Recently it was reported that a series of 8-benzyloxycaffeine analogues are potent reversible inhibitors of human monoamine oxidase (MAO) A and B. In an attempt to discover additional C8 oxy substituents of caffeine that ...
  • Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Strydom, Belinda (Thieme, 2012)
    Previous studies have documented that substituted 8-oxycaffeines act as inhibitors of human monoamine oxidase (MAO) B. A particularly potent inhibitor among the reported compounds was 8-(2-phenoxyethoxy)caffeine with an ...
  • Bergh, Jacobus Johannes; Mentz, Wayne; Mostert, Samantha; Petzer, Jacobus Petrus; Petzer, Anél (Elsevier, 2012)
    In a previous study we have investigated the monoamine oxidase (MAO) inhibitory properties of a series of 8-sulfanylcaffeine analogues. Among the compounds studied, 8-[(phenylethyl)sulfanyl]caffeine (IC50 = 0.223 lM) was ...
  • Bergh, Jacobus Johannes; Okaecwe, Thokozile Audrey Dorcas; Petzer, Jacobus Petrus; Swanepoel, Abraham Johannes; Petzer, Anél (Elsevier, 2012)
    A recent study has reported that a series of 8-benzyloxycaffeines are potent and reversible inhibitors of both human monoamine oxidase (MAO) isoforms, MAO-A and -B. In an attempt to discover additional caffeine derivatives ...
  • Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Manley-King, Clarina Ilara (Elsevier, 2011)
    Literature reports that isatin as well as C5- and C6-substituted isatin analogues are reversible inhibitors of human monoamine oxidase (MAO) A and B. In general, C5- and C6-substitution of isatin leads to enhanced ...
  • Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Manley-King, Clarina Ilara (Elsevier, 2011)
    Previous studies have shown that (E)-5-styrylisatin and (E)-6-styrylisatin are reversible inhibitors of human monoamine oxidase (MAO) A and B. Both homologues are reported to exhibit selective binding to the MAO-B isoform ...
  • Legoabe, Lesetja Jan; Petzer, Jacobus Petrus; Kruger, Johann; Petzer, Anél; Bergh, Jacobus J. (Elsevier, 2012)
    Chromone has been reported to be a useful scaffold for the design of monoamine oxidase (MAO) inhibitors. In an attempt to discover highly potent MAO inhibitors and to contribute to the known structureeactivity relationships ...
  • Bergh, Jacobus Johannes; Petzer, Jacobus Petrus; Manley-King, Clarina Ilara (Elsevier, 2012)
    It was recently reported that a series of C5-substituted phthalimides are remarkably potent reversible inhibitors of recombinant human monoamine oxidase (MAO) B. Modeling studies suggested that the phthalimide ring forms ...
  • Legoabe, Lesetja Jan; Petzer, Jacobus Petrus; Petzer, Anél (Elsevier, 2012)
    A previous study has shown that a series of C6-benzyloxy substituted chromones exhibit high binding affinities for human monoamine oxidase (MAO) B. In an attempt to discover additional chromones with potent and selective ...
  • Bergh, Jacobus Johannes; Booysen, Hermanus Perold; Moraal, Christina Maria; Petzer, Jacobus Petrus; Petzer, Anél; Terre'Blanche, Gisella (Elsevier, 2011)
    In a recent study it was shown that 8-benzyloxycaffeine analogues act as potent reversible inhibitors of human monoamine oxidase (MAO) A and B. Although the benzyloxy side chain appears to be particularly favorable for ...

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