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Leptin and its relation to autonomic activity, endothelial cell activation and blood pressure in a young black and white population: the African-PREDICT study

Ahiante, Blessing O.; Smith, Wayne; Lammertyn, Leandi; Schutte, Aletta E. (Thieme, 2018)

An increasing prevalence of obesity-related hypertension is observed in the youth and may have severe consequences for future cardiovascular disease development. Previous studies portrayed leptin as a potential factor ...

Large artery stiffness is associated with salt intake in young healthy black but not white adults: the African-PREDICT study + Correction to article

Strauss, Michél; Smith, Wayne; Kruger, Ruan; Van der Westhuizen, Bianca; Schutte, Aletta E. (Springer, 2018)

Purpose There is global consensus on the benefits of reducing excessive salt intake. Indeed, lower salt intake associates with reduced arterial stiffness, a well-established predictor of cardiovascular risk, in older ...

Marinobufagenin and left ventricular mass in young adults: the African-PREDICT study

Strauss, Michél; Smith, Wayne; Kruger, Ruan; Schutte, Aletta E.; Wei, Wen (Sage, 2018)

Background The endogenous steroidal inhibitor of sodium–potassium-dependent adenosine triphosphate and natriuretic hormone, marinobufagenin, plays a physiological role in ionic homeostasis. Animal models suggest that ...

Large artery stiffness is associated with marinobufagenin in young adults: the African-PREDICT study

Strauss, Michél; Smith, Wayne; Schutte, Aletta E.; Wei, Wen; Bagrov, Alexei Y. (Wolters Kluwer, 2018)

Objectives: The cardiotonic steroid, marinobufagenin (MBG), has been shown to play a physiological natriuretic role in response to salt intake. However, recent studies in clinical and animal models demonstrated possible ...

Bioavailable IGF-1 is beneficially associated with biomarkers of endothelial function in young healthy adults: the African-PREDICT study

Barnard, Sunelle A.; Smith, Wayne; Mels, Catharina M.C.; Botha, Shani; Schutte, Aletta E. (Elsevier, 2018)

Low circulating levels of insulin-like growth factor-1 (IGF-1) are associated with endothelial dysfunction, subsequently leading to the development of cardiovascular disease. Objective To better understand the early ...

Marinobufagenin is related to elevated central and 24-h systolic blood pressures in young black women: the African-PREDICT study

Strauss, Michél; Smith, Wayne; Schutte, Aletta E.; Wei, Wen; Fedorova, Olga V. (Nature, 2018)

Marinobufagenin (MBG) is an endogenous steroidal α1-Na+K+-ATPase inhibitor. Because of its role in sodium handling, MBG has been associated with both antihypertensive and prohypertensive effects in normal physiology and ...