Now showing items 1-5 of 5
Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux
Purpose Efflux transporters of the adenosine triphosphate-binding cassette (ABC)-superfamily play an important role in the development of multidrug resistance (multidrug resistant; MDR) in cancer. The overexpression of ...
Treatment of skin disorders with aloe materials
(Bentham Science, 2019)
The skin is the largest organ and functions as a barrier to protect the underlying tissues against the elements and pathogens, while also fulfilling many physiological roles and biochemical functions such as preventing ...
Drug bioavailability enhancing agents of natural origin (bioenhancers) that modulate drug membrane permeation and pre-systemic metabolism
Many new chemical entities are discovered with high therapeutic potential, however, many of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility and/or poor membrane permeation characteristics. ...
Aloe vera gel and whole leaf extract: functional and versatile excipients for drug delivery?
(Taylor & Francis, 2019)
Aloe vera (L.) Burm.f. (Aloe barbadensis Miller) is a perennial xerophyte plant that has many medicinal applications. A. vera leaves contain water storage tissue, which is fundamentally made up of a viscous mucilage contained ...
A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model
Ethnopharmacology relevance Traditional herbal medicines are utilized by 27 million South Africans. Xysmalobium undulatum (Uzara) is one of the most widely used traditional medicinal plants in Southern Africa. A false ...