Now showing items 1-6 of 6
Determination of the therapeutic efficacy of a novel Pheroid® formulation in a rodent tuberculosis model
Resistance against the current TB treatment regimens is spreading. A combination of the current TB regime with a novel drug delivery system, might lead to reduced resistance, shorter treatment durations and increased ...
Development of an LC-MS/MS method for the quantification of goserelin from Pheroid® formulation
The oral route is for many reasons the most common route of drug administration, however, due to gastrointestinal (GI) tract enzymatic stability issues, peptide drugs are administered parenterally. Goserelin is an ...
Safety pharmacology of herbal medicines in South Africa
The use of herbal medicine for treating various ailments has a deep history in South African traditional medicine. South Africa has a rich floral biodiversity which has been exploited for centuries mainly for day-to-day ...
Evaluation of the oral delivery of a peptide with Pheroid® technology
Goserelin is a type of hormone therapy used in addition to standard adjuvant therapy. Currently, goserelin is only available as a slow releasing subcutaneous implant but this is an invasive and generally not well- tolerated ...
The effect of entrapment of a peptide in Pheroid® on pharmacokinetics and testosterone levels
Goserelin is a peptide drug that suppresses levels of testosterone and oestradiol . The current formulation is presented in a sustained-release depot with several approved indications such as treatment of endometriosis, ...
A toxicity profile of the Pheroid® technology in rodents
The Pheroid® drug delivery system is now on the threshold of progressing into human clinical trials for various patented pharmaceutical applications and a systematic investigation of its toxicological properties in vitro ...