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Development of an LC-MS/MS method for the quantification of goserelin from Pheroid® formulation
(Elsevier, 2019)
The oral route is for many reasons the most common route of
drug administration, however, due to gastrointestinal (GI) tract
enzymatic stability issues, peptide drugs are administered parenterally. Goserelin is an ...
The effect of entrapment of a peptide in Pheroid® on pharmacokinetics and testosterone levels
(Elsevier, 2019)
Goserelin is a peptide drug that suppresses levels of testosterone
and oestradiol [1]. The current formulation is presented in a
sustained-release depot with several approved indications such as
treatment of endometriosis, ...
Determination of the therapeutic efficacy of a novel Pheroid® formulation in a rodent tuberculosis model
(Elsevier, 2019)
Resistance against the current TB treatment regimens is spreading. A combination of the current TB regime with a novel drug
delivery system, might lead to reduced resistance, shorter treatment
durations and increased ...
Safety pharmacology of herbal medicines in South Africa
(Elsevier, 2019)
The use of herbal medicine for treating various ailments has a
deep history in South African traditional medicine. South Africa has a
rich floral biodiversity which has been exploited for centuries mainly
for day-to-day ...
Evaluation of the oral delivery of a peptide with Pheroid® technology
(Elsevier, 2019)
Goserelin is a type of hormone therapy used in addition to standard
adjuvant therapy. Currently, goserelin is only available as a slow
releasing subcutaneous implant but this is an invasive and generally not well- tolerated ...
A toxicity profile of the Pheroid® technology in rodents
(Elsevier, 2019)
The Pheroid® drug delivery system is now on the threshold of progressing into human clinical trials for various patented pharmaceutical applications and a systematic investigation of its toxicological properties in vitro ...