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The cardiovascular safety of Pheroid® in the conscious rat
(Elsevier, 2019)
The Pheroid® technology is a patented colloidal drug delivery
system comprised of a dispersed oil phase of omega 3 and omega 6
fatty acids emulsified in N2O saturated water. Pheroid® has
pharmaceutical applicability for ...
Considerations for an in vitro, cell-based testing platform for detection of drug-induced inotropic effects in early drug development. Part 2. Designing and fabricating microsystems for assaying cardiac contractility with physiological relevance using human iPSC-cardiomyocytes
(Frontiers Media, 2019)
Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human ...
Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes
(PLoS, 2019)
We compared a published computational model of the action potential of a specific type of human induced pluripotent stem cell -derived cardiomyocytes (hiPSC-CM) with experimental field potential data with regard to their ...
Drug safety Africa: an overview of safety pharmacology & toxicology in South Africa
(Elsevier, 2019)
This meeting report is based on presentations given at the first Drug Safety Africa Meeting in Potchefstroom, South Africa from November 20–22, 2018 at the North-West University campus. There were 134 attendees (including ...
Considerations for an in vitro, cell-based testing platform for detection of adverse drug-induced inotropic effects in early drug development. Part 1: General considerations for development of novel testing platforms
(Frontiers Media, 2019)
Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted ...