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Selected C8 two-chain linkers enhance the adenosine A1/A2A receptor affinity and selectivity of caffeine
(Elsevier, 2017)
Recent research exploring C8 substitution on the caffeine core identified 8-(2-phenylethyl)-1,3,7-trimethylxanthine as a non-selective adenosine receptor antagonist. To elaborate further, we included various C8 two-chain-length ...