Search
Now showing items 1-10 of 64
The interactions of caffeine with monoamine oxidase
(Elsevier, 2013)
Aims: Caffeine has been used as a scaffold for the design of inhibitors of monoamine oxidase (MAO) A and B.
Substitution at the C8 position with a variety of moieties yields structures with high MAO inhibition ...
The monoamine oxidase inhibition properties of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one derivatives
(Springer, 2020)
Quinazolinone compounds are of interest in medicinal chemistry since they display a wide range of biological properties. In the present study, a series of C6- and N1-substituted 3-methyl-3,4-dihydroquinazolin-2(1H)-one ...
The design and evaluation of an l-dopa-lazabemide prodrug for the treatment of Parkinson’s disease
(MDPI, 2017)
l-Dopa, the metabolic precursor of dopamine, is the treatment of choice for the symptomatic relief of the advanced stages of Parkinson’s disease. The oral bioavailability of l-dopa, however, is only about 10% to 30%, and ...
Inhibition of monoamine oxidase by phthalide analogues
(Elsevier, 2013)
Based on recent reports that the small molecules, isatin and phthalimide, are suitable scaffolds for the
design of high potency monoamine oxidase (MAO) inhibitors, the present study examines the MAO inhibitory
properties ...
Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors
(Elsevier, 2013)
A series of 4-substituted-2-thiazolylhydrazone derivatives have been synthesized and tested in vitro for
their human monoamine oxidase (hMAO) A and B inhibitory activity. Our findings confirmed that the
substitution at ...
Evaluation of natural and synthetic 1,4-naphthoquinones as inhibitors of monoamine oxidase
(Wiley, 2016)
Previous reports have documented that 1,4-naphtho-
quinones act as inhibitors of the monoamine oxidase
(MAO) enzymes. In particular, fractionation of the
extracts of cured tobacco leafs has led to the charac-
terization ...
2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2016)
In the present study, a series of twenty-two 2-benzylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 2-benzylidene-1-indanone derivatives ...
Inhibition of monoamine oxidase by benzoxathiolone analogues
(Elsevier, 2016)
Inhibitors of the monoamine oxidase (MAO) enzymes are considered useful therapeutic agents, and are used in the clinic for the treatment of depressive illness and Parkinson’s disease. In addition, MAO inhibitors are also ...
2-Heteroarylidene-1-indanone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2016)
In the present study a series of fifteen 2-heteroarylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. These compounds are structurally related ...
The synthesis and evaluation of sesamol and benzodioxane derivatives as inhibitors of monoamine oxidase
(Elsevier, 2015)
In the present study, series of eight sesamol (1,3-benzodioxol-5-ol) and eight benzodioxane (2,3-dihydro-1,4-benzodioxine) derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase ...