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Depression symptoms facilitated fibrinolytic dysregulation and future coronary artery disease risk in a black male cohort: the sympathetic activity and ambulatory blood pressure in Africans study
(Wolters Kluwer, 2017)
Background: Hypercoagulation is associated with coronary artery disease (CAD). Whether depression symptoms dysregulate inflammatory and hemostatic markers in an African cohort is not known; therefore, we assessed the ...
Using MutPred derived mtDNA load scores to evaluate mtDNA variation in hypertension and diabetes in a two-population cohort: the SABPA study
(Elsevier, 2017)
Mitochondrial DNA (mtDNA) variation has been implicated in many common complex diseases, but inconsistent and contradicting results are common. Here we introduce a novel mutational load hypothesis, which also considers the ...
Chronic defensiveness and neuroendocrine dysfunction reflect a novel cardiac troponin T cut point: the SABPA study
(Elsevier, 2017)
Background
Sympatho-adrenal responses are activated as an innate defense coping (DefS) mechanism during emotional stress. Whether these sympatho-adrenal responses drive cardiac troponin T (cTnT) increases are unknown. ...
Defensive coping and essential amino acid markers as possible predictors for structural vascular disease in an African and Caucasian male cohort: the SABPA study
(Wiley, 2017)
Defensive coping (DefS), oxidative stress, inflammation, and related amino acids (phenylalanine [Phe] and tyrosine [Tyr]) have been implicated in cardiovascular disease. This study assessed whether inflammation, oxidative ...
Association between objectively measured physical activity, chronic stress and leukocyte telomere length
(Edizioni Minerva Medica, 2017)
BACKGROUND: Physical activity (PA ) attenuates chronic stress and age-related and cardiovascular disease risks, whereby potentially slowing
telomere shortening. We aimed to study the association between seven-day objectively ...
The protective role of oestradiol against silent myocardial ischemia and hypertension risk in South African men: the SABPA study
(Elsevier, 2017)
Background
Oestradiol has a protective effect on coronary artery health in women but the effect it has on men, is controversial. A translational approach was followed to assess whether sex hormone levels are associated ...
Troponin T release is associated with silent myocardial ischaemia in black men: the SABPA study
(Sage, 2017)
Background
High sensitivity cardiac troponin T (hs-cTnT) is a validated marker of myocardial damage and may reflect the degree of silent myocardial ischaemia (SMI) and ventricular strain. Our aim was to compare hs-cTnT ...