Search
Now showing items 1-10 of 45
Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: effect of ketamine
(Wiley, 2017)
Major depressive disorder (MDD) is associated with dysfunctional serotonergic and glutamatergic neurotransmission, and the genetic animal model of depression Flinders Sensitive Line (FSL) rats display alterations in these ...
Chronic restraint stress increases the protein expression of VEGF and its receptor VEGFR-2 in the prefrontal cortex
(Wiley, 2015)
In the present study the central and peripheral regulation of VEGF, its cognate receptors, and regulators were examined after acute and chronic restraint stress in rats. After chronic restraint stress (6 h per day for 21 ...
Decreased in vivo α2 adrenoceptor binding in the Flinders Sensitive Line rat model of depression
(Elsevier, 2015)
Depression is a debilitating heterogenous disorder and the underlying mechanisms remain elusive. Alterations in monoaminergic neurotransmission, including noradrenergic, have been implicated in the etiology of depression. ...
Nitric oxide involvement in the antidepressant-like effect of ketamine in the Flinders sensitive line rat model of depression
(Cambridge Univ Press, 2015)
Objective: We investigated whether the nitric oxide (NO) precursor,
L-arginine, can prevent the antidepressant-like action of the fast-acting
antidepressant, ketamine, in a genetic rat model of depression, and/or
induce ...
Electroconvulsive shocks decrease α2-adrenoceptor binding in the Flinders rat model of depression
(Elsevier, 2015)
Despite years of drug development, electroconvulsive therapy (ECT) remains the most effective treatment for severe depression. The exact therapeutic mechanism of action of ECT is still unresolved and therefore we tested ...
Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour
(Cambridge Univ Press, 2015)
Objective: Gut microbiota (GM) has previously been associated with alterations in rodent behaviour, and since the GM is affected by the diet, the composition of the diet may be an important factor contributing to behavioural ...
Expression of inflammatory markers in a genetic rodent model of depression
(Elsevier, 2015)
The complex bidirectional communication between the central nervous system and the peripheral immune system is of possible relevance for both normal brain functions and the development of psychiatric disorders. The aim of ...
GLP-1 receptor agonists have a sustained stimulatory effect on corticosterone release after chronic treatment
(Cambridge Univ Press, 2015)
Objective: Glucagon-like peptide 1 (GLP-1) receptor agonists are a new
group of antidiabetic medications quickly gaining popularity. We aimed to
examine behavioural and neuroendocrine changes following chronic
treatment ...
Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression
(Springer, 2016)
Rationale
The mechanisms mediating ketamine’s antidepressant effect have only been partly resolved. Recent preclinical reports implicate serotonin (5-hydroxytryptamine; 5-HT) in the antidepressant-like action of ketamine. ...
A new efficient method for synaptic vesicle quantification reveals differences between medial prefrontal cortex perforated and nonperforated synapses
(Wiley, 2014)
Communication between neurons is mediated by the
release of neurotransmitter-containing vesicles from
presynaptic terminals. Quantitative characterization of
synaptic vesicles can be highly valuable for understanding
...