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Thiobarbituric acid-reactive substances relate to arterial stiffness and blood pressure in 6 to 8-year-old boys stratified by maternal risk

Craig, Ashleigh; Mels, Catharina M.C.; Kruger, Ruan (Nature, 2018)

Early cardiovascular disease (CVD) onset can be inflicted by familial cardiovascular and lifestyle risk factors. We aimed to compare phenotypic characteristics and explore associations between oxidative stress and vascular ...

Large artery stiffness is associated with salt intake in young healthy black but not white adults: the African-PREDICT study + Correction to article

Strauss, Michél; Smith, Wayne; Kruger, Ruan; Van der Westhuizen, Bianca; Schutte, Aletta E. (Springer, 2018)

Purpose There is global consensus on the benefits of reducing excessive salt intake. Indeed, lower salt intake associates with reduced arterial stiffness, a well-established predictor of cardiovascular risk, in older ...

Marinobufagenin and left ventricular mass in young adults: the African-PREDICT study

Strauss, Michél; Smith, Wayne; Kruger, Ruan; Schutte, Aletta E.; Wei, Wen (Sage, 2018)

Background The endogenous steroidal inhibitor of sodium–potassium-dependent adenosine triphosphate and natriuretic hormone, marinobufagenin, plays a physiological role in ionic homeostasis. Animal models suggest that ...

Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings

Tsikas, Dimitrios; Kruger, Ruan; Hanff, Erik; Bollenbach, Alexander; Pham, Vu Vi (Springer, 2018)

We recently found that renal carbonic anhydrase (CA) is involved in the reabsorption of inorganic nitrite (NO2−), an abundant reservoir of nitric oxide (NO) in tissues and cells. Impaired NO synthesis in the endothelium ...

GC-MS quantification of urinary symmetric dimethylarginine (SDMA), a whole-body symmetric l-arginine methylation index

Bollenbach, Alexander; Kruger, Ruan; Hanff, Erik; Beckmann, Bibiana; Tsikas, Dimitrios (Elsevier, 2018)

Circulating and excretory NG,N´G-dimethyl-l-arginine (symmetric dimethylarginine, SDMA) and NG,NG-dimethyl-l-arginine (asymmetric dimethylarginine, ADMA) are cardiovascular risk factors. Despite close chemical structures, ...

Left ventricular mass independently associates with masked hypertension in young healthy adults: the African-PREDICT study

Sekoba, Nare P.; Kruger, Ruan; Schutte, Aletta E.; Labuschagne, Pieter (Wolters Kluwer, 2018)

Objective: Masked hypertension is reportedly common in young adults. However, it is unknown if these masked hypertensive individuals already present with organ damage. We determined whether a relationship exists between ...