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Drug bioavailability enhancing agents of natural origin (bioenhancers) that modulate drug membrane permeation and pre-systemic metabolism
(MDPI, 2019)
Many new chemical entities are discovered with high therapeutic potential, however, many of these compounds exhibit unfavorable pharmacokinetic properties due to poor solubility and/or poor membrane permeation characteristics. ...
Aloe vera gel and whole leaf extract: functional and versatile excipients for drug delivery?
(Taylor & Francis, 2019)
Aloe vera (L.) Burm.f. (Aloe barbadensis Miller) is a perennial xerophyte plant that has many medicinal applications. A. vera leaves contain water storage tissue, which is fundamentally made up of a viscous mucilage contained ...
A sub-chronic Xysmalobium undulatum hepatotoxicity investigation in HepG2/C3A spheroid cultures compared to an in vivo model
(Elsevier, 2019)
Ethnopharmacology relevance
Traditional herbal medicines are utilized by 27 million South Africans. Xysmalobium undulatum (Uzara) is one of the most widely used traditional medicinal plants in Southern Africa. A false ...
Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux
(Springer, 2019)
Purpose
Efflux transporters of the adenosine triphosphate-binding cassette (ABC)-superfamily play an important role in the development of multidrug resistance (multidrug resistant; MDR) in cancer. The overexpression of ...