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Paracellular drug absorption enhancement through tight junction modulation
(Taylor & Francis, 2013)
Introduction: Inclusion of absorption-enhancing agents in dosage forms is one approach to improve the bioavailability of active pharmaceutical ingredients with low membrane permeability. Tight junctions are dynamic protein ...
Overweight impairs efficacy of iron supplementation in iron-deficient South African children: a randomized controlled intervention
(Nature Publishing Group, 2013)
BACKGROUND: Many countries in the nutrition transition have high rates of iron deficiency (ID) and overweight (OW). ID is more
common in OW children; this may be due to adiposity-related inflammation reducing iron ...
Nocturnal blood pressure, 3-methoxy-4-hydroxyphenylglycol and carotidIntima-media thickness: the SABPA Study
(Elsevier, 2013)
Background: Research demonstrated a significant relationship between elevated nocturnal blood pressure and sym-pathetic hyperactivity. The study aimed to investigate possible associations between norepinephrine ...
Antiplasmodial activity and cytotoxicity of 10β-aminoquinolinylethylethers of artemisinin
(Thieme, 2013)
Each year roughly 800 000 people die of malaria, with 95% being African children. The shortcomings of the current drugs and the emergence of P. falciparum resistance to the artemisinin class of compounds warrant the search ...
Selected furanochalcones as inhibitors of monoamine oxidase
(Elsevier, 2013)
The validity of the chalcone scaffold for the design of inhibitors of monoamine oxidase has previously
been illustrated. In a systematic attempt to investigate the effect of heterocyclic substitution on the
monoamine ...
Solution-mediated phase transformation of different roxithromycin solid-state forms: implications on dissolution and solubility
(Elsevier, 2013)
The objective of this study was to describe the solid-state forms in which roxithromycin may exist and
the significant influence of solution-mediated phase transformation on the dissolution and solubility
behavior of ...
The effect of a multidisciplinary physical activity intervention on the body composition and physical fitness of obese children
(Minerva Medica, 2013)
AIM:
The aim was to determine the effect of a physical activity, diet, and behaviour modification intervention of 13 weeks, 3x per week for 60 minutes on the body composition and physical fitness of overweight and obese ...
The use of heart rates and graded maximal test values to determine rugby union game intensities
(Lippincott, Williams & Wilkins, 2013)
The aim of this study was to determine the intensities of university rugby union games using heart rates and graded maximal test values. Twenty-one rugby players performed a standard incremental maximal oxygen uptake ...