Now showing items 1-4 of 4
Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression. I. Bio-behavioural validation and response to imipramine
(Cambridge Univ Press, 2017)
Co-morbid depression with post-traumatic stress disorder (PTSD) is often treatment resistant. In developing a preclinical model of treatment-resistant depression (TRD), we combined animal models of depression and PTSD to ...
S-ketamine rapidly reverses synaptic and vascular deficits of hippocampus in genetic animal model of depression
(Oxford Univ Press, 2017)
Background: The neurovascular plasticity of hippocampus is an important theory underlying major depression. Ketamine as a novel glutamatergic antidepressant drug can induce a rapid antidepressant effect within hours. In ...
The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex
It is well established that stress plays a major role in the pathogenesis of neuropsychiatric diseases. Stress-induced alteration of synaptic plasticity has been hypothesized to underlie the morphological changes observed ...
The α2C-adrenoceptor antagonist, ORM-10921, exerts antidepressant-like effects in the Flinders Sensitive Line rat
(Wolters Kluwer, 2017)
Depression involves deficits in monoaminergic neurotransmission. Differential roles for α2A, B and C subtypes of the α2-adrenoceptor (AR) are evident, with selective α2C-AR antagonists purported to have antidepressant and ...