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A psycho-behavioral perspective on modelling obsessive-compulsive disorder (OCD) in animals: the role of context
(Bentham Science, 2017)
Obsessive-compulsive disorder is a heterogeneous and debilitating condition, characterized by intrusive thoughts and compulsive repetition. Animal models of OCD are important tools that have the potential to contribute ...
Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression. II. Response to antidepressant augmentation strategies
(Cambridge Univ Press, 2017)
Post-traumatic stress disorder (PTSD) displays high co-morbidity with major depression and treatment-resistant depression (TRD). Earlier work demonstrated exaggerated depressive-like symptoms in a gene×environment model ...
Exploring a post-traumatic stress disorder paradigm in Flinders sensitive line rats to model treatment-resistant depression. I. Bio-behavioural validation and response to imipramine
(Cambridge Univ Press, 2017)
Co-morbid depression with post-traumatic stress disorder (PTSD) is often treatment resistant. In developing a preclinical model of treatment-resistant depression (TRD), we combined animal models of depression and PTSD to ...
Social behavior in deer mice as a novel interactive paradigm of relevance for obsessive-compulsive disorder (OCD)
(Taylor & Francis, 2017)
Greater obsessive-compulsive (OC) symptom severity may be associated with poor social adjustment. Rather than possessing deficits in social skill per se, OCD patients may be more socially isolative in the presence of normal ...
Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats
(Elsevier, 2017)
Major depressive disorder (MDD) is highly associated with dysmetabolic conditions, such as obesity and diabetes mellitus type 2, and the gut microbiota may interact with both disease entities. We have previously shown that ...