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Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity
(Society for Neuroscience, 2015)
Neuropeptide S (NPS) has generated substantial interest due to its anxiolytic and fear-attenuating effects in rodents, while a corresponding
receptor polymorphism associated with increased NPS receptor (NPSR1) surface ...
Antidepressant-like effect of sodium butyrate is associated with an increase in TET1 and in 5-hydroxymethylation levels in the Bdnf gene
(Oxford Univ Press, 2015)
Background: Epigenetic drugs like sodium butyrate (NaB) show antidepressant-like effects in preclinical studies, but the exact molecular mechanisms of the antidepressant effects remain unknown. While research using NaB has ...
Telomerase dysregulation in the hippocampus of a rat model of depression: normalization by lithium
(Oxford Univ Press, 2015)
Background: Telomeres are protective DNA-protein complexes at the ends of each chromosome, maintained primarily by the enzyme telomerase. Shortening of the blood leukocyte telomeres is associated with aging, several chronic ...