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Nocturnal blood pressure, 3-methoxy-4-hydroxyphenylglycol and carotidIntima-media thickness: the SABPA Study
(Elsevier, 2013)
Background: Research demonstrated a significant relationship between elevated nocturnal blood pressure and sym-pathetic hyperactivity. The study aimed to investigate possible associations between norepinephrine ...
Extracellular matrix biomarker, Fibulin–1 and Its association with Soluble uPAR in a Bi-ethnic South African population: the SAfrEIC study
(Elsevier, 2015)
Background
Fibulin-1 and soluble urokinase-type plasminogen activator receptor (suPAR) emerged as mediators in the development of sclerotic disease. SuPAR along with C-reactive protein (CRP) and albumin delineate ...
Effects of acute and chronic stress on the L-arginine nitric oxide pathway in black and white South Africans: the sympathetic activity and ambulatory blood pressure in Africans study
(Lippincott, Williams & Wilkins, 2013)
OBJECTIVE:
This study investigated the impact of stress on effectors of the L-arginine/nitric oxide (NO) system including the endogenous inhibitor asymmetric dimethylarginine (ADMA).
METHODS:
Black (n = 168) and white ...
Soluble urokinase plasminogen activator receptor and hypertension among black South Africans after 5 years
(Nature Publishing Group, 2015)
Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker that links inflammation with cardiovascular risk. "However, studies linking suPAR and hypertension are scant. First, we determined whether baseline ...
Compromised bioavailable IGF-1 of black men relates favourably to ambulatory blood pressure: the SABPA study
(Elsevier, 2014)
Objectives
Insulin-like growth factor-1 (IGF-1) has potent endothelial-protective, anti-platelet and anti-thrombotic activities, and also exerts mitogenic and proliferatory actions on vascular smooth muscle cells. Conflicting ...
Associations of suPAR with lifestyle and cardiometabolic risk factors
(Wiley, 2014)
Background: Soluble urokinase plasminogen activator receptor (suPAR), a novel indicator of low-grade inflammation, is associated with cardiovascular disease and mortality in the general population, while an unhealthy ...
Attenuated NOx responses and myocardial ischemia, a possible risk for structural vascular disease in African men: the SABPA study
(Nature Publishing Group, 2014)
Chronically elevated blood pressure has been associated with impaired NO-mediated vasodilation and structural vascular disease risk. This study aimed to determine whether significant associations exist regarding NO metabolite ...
The relationship of nitric oxide synthesis capacity, oxidative stress, and albumin-to-creatinine ratio in black and white men: the SABPA study
(Springer, 2016)
Inadequate substrate availability and increased
nitric oxide synthase inhibitor levels attenuate nitric oxide
(NO) synthesis, whereas increased vascular oxidative
stress may lead to inactivation of NO. We compared
markers ...
Associations of central and peripheral blood pressure with the renin-angiotensin-aldosterone system in healthy young adults: the African-PREDICT study
(Springer Nature, 2020)
This study investigated associations of brachial and central blood pressure (BP) with detailed renin-angiotensin-aldosterone system (RAAS) components in a healthy young population stratified according to ethnicity and sex. ...
Differences in MetS marker prevalence between black African and Caucasian teachers from the North West Province: Sympathetic activity and ambulatory blood pressure in Africans (SABPA) study
(Medpharm, 2011)
Background: The aim of this study was to compare metabolic syndrome (MetS) prevalence between black and Caucasian Africans using different definitions, and secondly, to determine the association between MetS, anthropometric ...