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The rat hippocampal gliovascular system following one week vortioxetine and fluoxetine
(Elsevier, 2020)
We have previously reported that vortioxetine, unlike the selective serotonin reuptake inhibitor fluoxetine, produces a rapid increase of dendritic spine number and Brain Derived Neurotrophic Factor (BDNF)-associated ...
Neurovascular plasticity of the hippocampus one week after a single dose of ketamine in genetic rat model of depression
(Wiley, 2016)
Glutamatergic system and the structural plasticity hypothesis are principal components for rapid and sustained antidepressant effects of novel antidepressant therapeutics. This study represents the first investigation of ...
Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus
(Wiley, 2017)
Background and purpose
Astroglia contribute to the pathophysiology of major depression and antidepressant drugs act by modulating synaptic plasticity; therefore, the present study investigated whether the fast antidepressant ...
Autistic-like behaviours and associated brain structural plasticity are modulated by oxytocin in maternally separated rats
(Elsevier, 2020)
Background
Early psycho-social experiences influence the developing brain and possible onset of various neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD). ASD is characterized by a variety of brain ...
Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner
(Elsevier, 2020)
The prevalence of major depressive disorder (MDD) is higher in women than men. Importantly, a differential behavioral response by sex to the antidepressant response to ketamine in rodents has been reported. Mechanistically, ...
Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery
(Elsevier, 2020)
Background
Depression is a common complication of stroke and increases the risk of mortality and disability. Pre-stroke depression is a possible risk factor for stroke and has also been linked to adverse outcomes. The ...