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Using MutPred derived mtDNA load scores to evaluate mtDNA variation in hypertension and diabetes in a two-population cohort: the SABPA study
(Elsevier, 2017)
Mitochondrial DNA (mtDNA) variation has been implicated in many common complex diseases, but inconsistent and contradicting results are common. Here we introduce a novel mutational load hypothesis, which also considers the ...
Nitric oxide synthesis capacity, ambulatory blood pressure and end organ damage in a black and white population: the SABPA study
(Springer, 2016)
Nitric oxide (NO) synthesis capacity is determined by the availability of substrate(s) such as l-arginine and the influence of nitric oxide synthase (NOS) inhibitors, asymmetric dimethylarginine (ADMA) and symmetric ...
Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: a five-year prospective study
(Sage Publications Ltd, 2016)
Background:
Inconsistent findings are reported on whether insulin-like growth factor-1 (IGF-1) is protective or harmful
in predicting hypertension, carotid wall thickness and mortality. We determined the five-year ...