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    Evaluation of selected natural compounds as dual inhibitors of catechol-o-methyltransferase and monoamine oxidase 

    Engelbrecht, Idalet; Petzer, Jacobus P.; Petzer, Anél (Bentham Science, 2019)
    Background: The most effective symptomatic treatment of Parkinson’s disease remains the metabolic precursor of dopamine, L-dopa. To enhance the efficacy of L-dopa, it is often combined with inhibitors of the enzymes, ...
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    Novel monoamine oxidase inhibitors based on the privileged 2-imidazoline molecular framework 

    Shetnev, Anton; Petzer, Anél; Engelbrecht, Idalet; Petzer, Jacobus P.; Osipyan, Angelina (Elsevier, 2019)
    Series of structurally diverse 2-imidazoline derivatives have been synthesized by condensation of substituted aldehydes with ethylenediamine, Pd-catalyzed N-arylation of 2-imidazolines and by the formation of 1,2,4-oxadiazoles ...

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    Author
    Engelbrecht, Idalet (2)
    Petzer, Anél (2)Petzer, Jacobus P. (2)Osipyan, Angelina (1)Shetnev, Anton (1)Subject
    Inhibition (2)
    Monoamine oxidase (2)2-Imidazoline (1)Catechol-O-methyltransferase (1)MAO (1)Multi-target-directed (1)Natural compounds (1)Parkinson's disease (1)Selective (1)... View MoreDate Issued
    2019 (2)
    Has File(s)No (2)

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