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    Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazoles 

    Guglielmi, Paulo; Petzer, Anél; Petzer, Jacobus P.; Carradori, Simone; Poli, Giulio (MDPI, 2019)
    New N-acetyl/N-thiocarbamoylpyrazoline derivatives were designed and synthesized in high yields to assess their inhibitory activity and selectivity against human monoamine oxidase A and B. The most important chiral ...
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    4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis 

    Secci, Daniela; Petzer, Anél; Petzer, Jacobus P.; Carradori, Simone; Guglielmi, Paulo (Taylor & Francis, 2019)
    A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted ...
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    SAR and molecular mechanism studies of monoamine oxidase inhibition by selected chalcone analogs 

    Shalaby, Raed; Petzer, Jacobus P.; Petzer, Anél; Ashraf, Usman M.; Atari, Ealla (Taylor & Francis, 2019)
    The present study describes the synthesis of a series of 22 chalcone analogs. These compounds were evaluated as potential human MAO-A and MAO-B inhibitors. The compounds showed varied selectivity against the two isoforms. ...

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    AuthorPetzer, Anél (3)Petzer, Jacobus P. (3)Carradori, Simone (2)Guglielmi, Paulo (2)Ashraf, Usman M. (1)Atari, Ealla (1)Poli, Giulio (1)Secci, Daniela (1)Shalaby, Raed (1)Subject
    Monoamine oxidase (3)
    Molecular modelling (2)(Thiazol-2-yl)hydrazone derivatives (1)Alzheimer’s disease (1)Antioxidants (1)Chalcone (1)Dopamine (1)Enantioseparation (1)Inhibitor (1)mRNA (1)... View MoreDate Issued
    2019 (3)
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    Yes (3)

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