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Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models
(Elsevier, 2012)
Anxiety disorders are amongst the most common and disabling of psychiatric illnesses and have severe health
and socio-economic implications. Despite the availability of a number of treatment options there is still a
strong ...
Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo[1,2a]quinoxaline compounds
(Elsevier, 2012)
Series of bisquinolines 4e15 and bispyrrolo[1,2a]quinoxalines 16e20 containing various polyamine
linkers were synthesized. The aqueous solubility and distribution coefficient were experimentally
determined. The compounds ...
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)
Depressive disorders represent a significant health concern as they are associated with high social and
physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective
treatment ...
Biodistribution and pharmacokinetics of I-131 labelled 4- Iodophenylacetic acid
(Bentham Science, 2012)
Abstract: Phenylacetate has been reported to have a potent anti-proliferative and anti-differentiating effect in
haematological malignancies and in solid tumours at non-toxic concentrations. This study is a preliminary ...
The circumstances and needs of adolescent orphans in foster care
(University of Stellenbosch, 2012)
HIV and AIDS have a major impact on families and on community structures in South Africa. Children are especially affected when they are orphaned. Research was undertaken to identify the circumstances and needs of adolescent ...
Facilitated defensive coping, silent ischaemia and ECG left-ventricular hypertrophy: the SABPA study
(Kluwer, 2012)
Background: Defensive active coping responses (being-in-control, acceptance of the stressor as reality) have been associated with vascular hyper-responsiveness in urban Africans. However, the association between active ...
Sex hormones associated with subclinical kidney damage and atherosclerosis in South African men: the SABPA study
(Kluwer, 2012)
Background: Hypertension and increased blood glucose are associated with subclinical kidney damage, atherosclerosis and with low testosterone values. Low testosterone in men is often accompanied by increased levels of ...
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment
(Elsevier, 2012)
Schizophrenia is associated with increased oxidative stress, although the source of this redox disequilibrium
requires further study. Altered tryptophan metabolism has been described in schizophrenia,
possibly linked to ...
Selected chromone derivatives as inhibitors of monoamine oxidase
(Elsevier, 2012)
A previous study has shown that a series of C6-benzyloxy substituted chromones exhibit high binding affinities for human monoamine oxidase (MAO) B. In an attempt to discover additional chromones with potent and selective ...
Change over three years in adolescents’ physical activity levels and patterns after a physical activity intervention: play study
(Edizioni Minerva Medica, 2012)
AIM: This study aimed to determine over a three-year period what the PA levels and patterns of adolescents will be after participating in a physical activity (PA) intervention.
METHODS: African adolescents (158 boys, 211 ...