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The African prospective study on the early detection and identification of cardiovascular disease and hypertension (African-PREDICT): design, recruitment and initial examination
(Sage, 2019)
Background: Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of hypertension remains on an
increase. Although this might be attributed to poor healthcare and ineffective antihypertensive ...
The association of measures of the micro- and macro-vasculature with selenium and GPx activity in a young bi-ethnic population: the African-PREDICT study
(Taylor & Francis, 2019)
Objective: Selenium plays an important physiological role as component for antioxidant selenoproteins such as glutathione peroxidase (GPx). Since oxidative stress contributes to hypertension development, it is likely that ...
Retinal vasculature reactivity during flicker light provocation, cardiac stress and stroke risk in Africans: the SABPA study
(Springer, 2019)
Structural and functional similarities exist between the retinal, cerebral and, as previously suggested, the coronary microvasculature. Retinal microvascular structure and functionality (in response to flicker-light-indu ...
Leptin and the vasculature in young adults: the African‐PREDICT study
(Wiley, 2019)
Background and aim
Information regarding the effect of leptin on the vasculature in young healthy adults at risk for cardiovascular disease development is limited. We therefore examined the associations between measures ...
Iron loading, alcohol and mortality: a prospective study
(Elsevier, 2019)
Background & aims
The relationship between total body iron and cardiovascular disease remains controversial and information absent in black sub-Saharan Africans in whom alcohol consumption tends to be high. The level of ...
Stress and neurovascular coupling: a red flag? The SABPA study
(Karger, 2019)
Neuronal hyperactivity mediates communication between neurons and blood vessels (neurovascular coupling) and increases susceptibility for retinal ganglion
cells functionality. Contrastingly, monoamine depletion and ...
The Na+K+-ATPase inhibitor marinobufagenin and early cardiovascular risk in humans: a review of recent evidence
(Springer, 2019)
Purpose of Review
This review synthesizes recent findings in humans pertaining to the relationships between marinobufagenin (MBG), a steroidal Na+/K+-ATPase inhibitor and salt-sensitivity biomarker, and early cardiovascular ...
Heart rate variability and the dynamic nature of the retinal microvasculature: providing insight into the brain-retina-heart link: the SABPA study
(Karger, 2019)
Controversy exists regarding the contribution of
the autonomic nervous system (ANS) to the retinal microvasculature’s autoregulatory capacities. It was demonstrated that mean
retinal vessel responses to systemic sympathetic ...
Brain-derived-neurotrophic-factor, dynamic retinal vessel responses during flicker light and stroke risk: the SABPA study
(Karger, 2019)
Assessment of the retinal vessels’ structure and
function provides an automated and objective approach to noninvasively assess the condition of the cerebral microvasculature
and indicates susceptibility for stroke. ...
The oxidative stress profile and its relation to vascular function in a bi-ethnic cohort: the SABPA study
(Karger, 2019)
Oxidative stress and inflammation
has been implicated in arterial stiffness, and hypertension development. Oxidative stress may interfere with normal vascular function by inactivation of NO and/or the production of ...