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Now showing items 1351-1360 of 1391
New insights on the antidepressant discontinuation syndrome
(Wiley, 2014)
Objective Antidepressants are at best 50–55% effective. Non-compliance and the antidepressant discontinuation syndrome (ADS) are
causally related yet poorly appreciated. While ADS is associated with most antidepressants, ...
Evaluation of waist-to-height ratio to predict 5 year cardiometabolic risk in sub-Saharan African adults
(Open Access, 2014)
Background and aims Simple, low-cost central obesity measures may help identify individuals with increased cardiometabolic disease risk, although it is unclear which measures perform best in African adults. We aimed to: ...
Which dietary diversity indicator is best to assess micronutrient adequacy in children 1 to 9 y?
(Open Access, 2014)
Objectives
The aim of this study was to determine the best dietary diversity indicator to measure dietary diversity and micronutrient adequacy in children.
Methods
A national representative cross-sectional survey of ...
Development and validation of a LC-MS/MS method for the quantitation of lumefantrine in mouse whole blood and plasma
(Elsevier, 2015)
A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the quantitation of the antimalarial drug, lumefantrine (LF), in mouse whole blood and plasma. The analyte was extracted ...
The fabrication and characterization of a PLGA nanoparticle–Pheroid® combined drug delivery system
(Springer, 2017)
The combination of polymeric nanoparticles (NPs) as a core and lipid vesicles as a shell has emerged to be a robust and promising drug delivery strategy. This study explores the development of a novel combined delivery ...
Hypercoagulation and hyperkinetic blood pressure indicative of physiological loss-of-control despite behavioural control in Africans: the SABPA study
(Taylor & Francis, 2016)
Objectives: A dissociation between behavioural (in-control) and physiological parameters (indicating loss-of-control) is associated with cardiovascular risk in defensive coping (DefS) Africans. We evaluated relationships ...
Hyperpulsatile pressure, systemic inflammation and cardiac stress are associated with cardiac wall remodeling in an African male cohort: the SABPA study
(Nature, 2016)
Inflammation may contribute to an increase in cardiac wall stress through pathways related to cardiac remodeling. Cardiac remodeling is characterized by myocyte hypertrophy, myocyte death and modifications of the extracellular ...
In vivo efficacy and bioavailability of lumefantrine: evaluating the application of Pheroid technology
(Elsevier, 2015)
The oral absorption of compounds with low aqueous solubility, such as lumefantrine, is typically limited by the dissolution rate in the gastro-intestinal tract, resulting in erratic absorption and highly variable ...
Fibrosis and coronary perfusion: a cardiovascular disease risk in an African male cohort: the SABPA study
(Taylor & Francis, 2016)
Low-grade inflammation has been correlated with risk factors of cardiovascular diseases (CVD). Whether the pro-inflammatory and thrombotic ratio (fibrosis) may contribute to CVD is not known. We therefore aimed to assess ...
A dose-response crossover iodine balance study to determine iodine requirements in early infancy
(American Society for Nutrition, 2016)
Background: Optimal iodine intake during infancy is critical for
brain development, but no estimated average requirement (EAR) is
available for this age group.
Objective: We measured daily iodine intake, excretion, and ...