Now showing items 151-154 of 154
A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forward
Rodent marble-burying behavior in the marble-burying test (MBT) is employed as a model or measure to study anxiety- and compulsive-like behaviors or anxiolytic and anticompulsive drug action. However, the test responds ...
Morpho‐functional characteristics of bone marrow multipotent Mesenchymal Stromal Cells after activation or inhibition of epidermal growth factor and toll‐like receptors or treatment with DNA intercalator cisplatin
This study is aimed to reveal morphological and functional changes in multipotent mesenchymal stromal cells (MSCs) isolated from the rat bone marrow after: (i) activation of Toll‐like receptors (TLRs) with teichoic acid ...
The use of cytokines as indicators for drug safety
In developing new compounds, questions about safety and efficacy are raised. Conventional preclinical studies of new compounds focus on bio-distribution, toxicology, safety pharmacology, pharmacokinetics, efficacy etc., ...
Understanding well-being in the Ghanaian context: linkages between lay conceptions of well-being and measures of hedonic and eudaimonic well-being
The aim of this study was to explore the measurement and conceptualisation of well-being within the Ghanaian socio-cultural setting. In addition to testing the structural validity of two commonly used well-being scales, ...